{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:27:40Z","timestamp":1753878460901,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005275","name":"Region Hovedstaden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Myocardial work is a novel measure of potential value for diagnosing\u00a0coronary artery disease (CAD). It may therefore be useful in patients with chronic kidney disease (CKD), in whom the diagnostic work\u2010up can be challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study of patients with CKD (G1\u20105, nondialysis\u2010dependent). Cardiac computed tomography was performed to quantify coronary artery calcium score (CACS). Pressure\u2010strain loop analysis was performed to obtain global and territorial work index (GWI and TWI, respectively). Logistic regression was applied to investigate the association between work measures and high CACS (&gt;400).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 455 patients (age: 57 years, 60% men, 8% with previous CAD, and eGFR of 43\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>). High CACS across all coronary arteries was observed in 77 (17%), with 53 (12%) in the left anterior descending (LAD) artery, 28 (6%) in the right coronary artery (RCA), and 17 (4%) in the circumflex (Cx) artery.<\/jats:p><jats:p>No difference in GWI was observed for overall high versus non\u2010high CACS (1861\u00a0vs. 1937\u00a0mmHg%, <jats:italic>p<\/jats:italic> = 0.14). TWI was reduced in patients with high versus non\u2010high CACS in the LAD (1772\u00a0vs. 1956\u00a0mmHg%, <jats:italic>p<\/jats:italic> = 0.003) and in the Cx (1556\u00a0vs. 1934\u00a0mmHg%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), but not in the RCA (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.68). After multivariable regression, TWI remained significantly associated with high CACS in the LAD and Cx in patients with no history of CAD, but not in the RCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with CKD, GWI was not associated with an overall high CACS. TWI was, however, associated with a high CACS in specific coronary arteries, although the findings were inconsistent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.70064","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T11:35:14Z","timestamp":1735558514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Myocardial Work and Coronary Artery Calcium Score in Patients With Chronic Kidney Disease"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9511-8375","authenticated-orcid":false,"given":"Flemming Javier","family":"Olsen","sequence":"first","affiliation":[{"name":"Cardiovascular Non\u2010Invasive Imaging Research Laboratory, Department of Cardiology Copenhagen University Hospital \u2013 Herlev and Gentofte  Hellerup Denmark"},{"name":"Center for Translational Cardiology and Pragmatic Randomized Trials, Department of 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Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus Fuglsang","family":"Kofoed","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Feldt\u2010Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Nephrology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Nephrology Copenhagen University Hospital \u2010 Herlev and Gentofte  Herlev 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