{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T11:27:07Z","timestamp":1772018827924,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Right ventricular (RV) diastolic function and right atrial (RA) function are poorly characterized in patients with obstructive sleep apnea syndrome (OSAS), but may influence exercise capacity. We aimed to evaluate RA function and RV diastolic function in OSAS and study their relationship with exercise capacity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three patients with OSAS and thirty age\u2010 and gender\u2010matched controls prospectively underwent echocardiography and cardiopulmonary exercise testing to investigate RV diastolic function, RA function, and exercise capacity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altered RV diastolic function in patients with severe OSAS was indicated by the increased tricuspid valve E\/e\u2032 ratio (TV E\/e\u2032), isovolumic relaxation time (IVRT), and by the reduced RV TDI e\u2032 velocity. The TV E\/e\u2032 correlated modestly with peak VO<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic> = \u22120.334, <jats:italic>p<\/jats:italic> &lt;\u00a00.01). Patients with severe OSAS exhibited impaired RA total emptying fraction, RA passive emptying fraction, and RA reservoir strain (RARS), with RARS being associated with peak oxygen uptake (VO<jats:sub>2<\/jats:sub>) (<jats:italic>r<\/jats:italic> = 0.451, <jats:italic>p<\/jats:italic> &lt;\u00a00.01 for reservoir function).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Altered RA function and RV diastolic function in patients with OSAS are associated with impaired exercise capacity. The correlation of RA function and RV diastolic function with exercise capacity suggests that it may be important to evaluate RA function and RV diastolic function in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.70091","type":"journal-article","created":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T10:45:36Z","timestamp":1742121936000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Right Atrial Function and Right Ventricular Diastolic Function and Their Relation With Exercise Capacity in OSAS"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1873-7587","authenticated-orcid":false,"given":"Bang","family":"Du","sequence":"first","affiliation":[{"name":"Department of Echocardiography The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxin","family":"Liang","sequence":"additional","affiliation":[{"name":"Shenzhen Ruipuxun Academy for Stem Cell &amp; Regenerative Medicine  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Echocardiography The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjia","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Echocardiography The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruonan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Echocardiography The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahong","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Echocardiography The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiai","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Echocardiography The First Clinical Medical School of Gansu University of Chinese Medicine, Gansu Provincial Hospital  Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,16]]},"reference":[{"issue":"15","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1056\/NEJMcp1816152","article-title":"Obstructive Sleep Apnea in Adults","volume":"380","author":"Veasey S. 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