{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:30:07Z","timestamp":1770273007452,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T00:00:00Z","timestamp":1742515200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2025,3]]},"abstract":"ABSTRACT<\/jats:title>Purpose<\/jats:title>This study aims to elucidate the characteristics of segment myocardial work (MW) and reserve function through exercise stress echocardiography (ESE) and to explore the associations between MW parameters and exercise capacity in patients with left ventricular remodeling due to hypertension (LVRH).<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 105 patients with LVRH (LVMI \u2265\u00a0115\u00a0g\/m2<\/jats:sup> for males and LVMI \u2265\u00a095\u00a0g\/m2<\/jats:sup>for females) underwent ESE examination following established guidelines. Additionally, 59 healthy subjects served as a control group. Speckle tracking software was employed for analysis, calculating MW parameters by integrating longitudinal strain with the noninvasive left ventricular pressure curve. Global and segmental myocardial work indices, reserve function, and exercise capacity were evaluated and analyzed.<\/jats:p><\/jats:sec>Results<\/jats:title>The global work index (GWI), global constructive work (GCW), and global wasted work (GWW) were significantly elevated both at rest and peak in the LVRH group, whereas global work efficiency (GWE) was reduced. GWI shows an increasing trend from the basal to the apex, The apex segment GWI of the LVRH group exhibited the highest peak value (2754.5 \u00b1 231.0\u00a0mmHg), while there was no significant difference in peak GWI at the basal level between the two groups. The GWI\u2010rest and \u0394GWI showed significant correlation with exercise metabolic equivalent (MET) (r<\/jats:italic> = \u22120.502, p<\/jats:italic>\u00a0<\u00a00.001) and diastolic function E\/e\u2032\u2010peak (r<\/jats:italic> = 0.612, p<\/jats:italic> <0.001). Multivariable linear regression demonstrated that GWI\u2010rest, \u0394GWI provided powerful incremental value in independent associations with exercise capacity.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>MW parameters reflect the contractile force under hemodynamic overload, offering a more compelling perspective for evaluating cardiac function, including segments value. GWI\u2010rest and \u0394GWI is significantly correlated with exercise endurance in LVRH patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.70093","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T10:52:29Z","timestamp":1742727149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of Segmental Myocardial Work and Exercise Tolerance in Hypertension Patients With Left Ventricular Remodeling Through Stress Echocardiography"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-2357","authenticated-orcid":false,"given":"Qingfeng","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Medicine University of Electronic Science and Technology of China Chengdu China"},{"name":"Department of Key Laboratory in Cardiac Electrophysiology and Biomechanics and Cardiovascular Ultrasound Sichuan Provincial People's Hospital University of Electronic Science and Technology Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-9448","authenticated-orcid":false,"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Key Laboratory in Cardiac Electrophysiology and Biomechanics and Cardiovascular Ultrasound Sichuan Provincial People's Hospital University of Electronic Science and Technology Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongmei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Key Laboratory in Cardiac Electrophysiology and Biomechanics and Cardiovascular Ultrasound Sichuan Provincial People's Hospital University of Electronic Science and Technology Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geqi","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Key Laboratory in Cardiac Electrophysiology and Biomechanics and Cardiovascular Ultrasound Sichuan Provincial People's Hospital University of Electronic Science and Technology Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixue","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Medicine University of Electronic Science and Technology of China Chengdu China"},{"name":"Department of Key Laboratory in Cardiac Electrophysiology and Biomechanics and Cardiovascular Ultrasound Sichuan Provincial People's Hospital University of Electronic Science and Technology Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s10554-022-02762-1","article-title":"Prognostic Value of Left Ventricular Global Constructive Work in Patients With Cardiac Amyloidosis","volume":"39","author":"Geers J.","year":"2023","journal-title":"International Journal of Cardiovascular Imaging"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1119785","article-title":"The Value of Myocardial Work in the Estimation of Left Ventricular Systolic Function in Patients With Coronary Microvascular Disease: A Study Based on Adenosine Stress Echocardiography","volume":"10","author":"Liu Q.","year":"2023","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"5","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/HJH.0000000000002330","article-title":"Subclinical Left Ventricular Systolic Dysfunction by Two\u2010Dimensional Speckle\u2010Tracking Echocardiography and Its Relation to Ambulatory Arterial Stiffness Index in Hypertensive Patients","volume":"38","author":"Ahmed T. 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