{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:00:46Z","timestamp":1790827246560,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The mechanisms and clinical importance of acute reduction (ARD) in left ventricular (LV) function following transcatheter edge\u2010to\u2010edge repair (TEER) for mitral regurgitation (MR) remains unclear. This study aimed to non\u2010invasively evaluate the cardio\u2010mechanical parameters, including end\u2010systolic elastance (Ees) and arterial elastance (Ea), to explore their association with ARD following mitral TEER.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective analysis of serial transthoracic echocardiography (TTE) studies before and after mitral TEER. Cardio\u2010mechanical parameters were evaluated non\u2010invasively using a modified single\u2010beat method. After the exclusion of nine patients requiring intravenous catecholamine infusion, the study cohort comprised 49 consecutive patients (25 men; mean age: 81 \u00b1 9 years) with successful mitral TEER. ARD in LV function was defined as a decrease in LV ejection fraction (LVEF) of \u22655 points following the procedure by TTE, which was reported in 18 patients. The hospitalization period was longer in patients with ARD in LVEF than in those without ARD (5.5 days vs. 4 days,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.031). Following improvement in MR, Ea increased (1.54\u00a0\u00b1\u00a00.49\u00a0mmHg\/mL vs. 1.84\u00a0\u00b1\u00a00.55\u00a0mmHg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004). Linear regression analysis revealed a correlation between \u0394total stroke volume (SV) and \u0394Ea (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.614,\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u00a00.0001). Notably, \u0394Ea was higher in patients with ARD in LVEF than in those without ARD in LVEF (0.60\u00a0\u00b1\u00a00.73\u00a0mmHg\/mL vs. 0.14\u00a0\u00b1\u00a00.39\u00a0mmHg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ARD in LVEF after mitral TEER was reported in a substantial proportion of patients and may have prognostic implications. Evaluating cardio\u2010mechanical parameters may aid in understanding complex hemodynamics and guiding treatment strategies for patients with MR undergoing TEER.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70095","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T20:18:22Z","timestamp":1739218702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased Afterload in Patients With Acute Reduction in Left Ventricular Ejection Fraction Following Mitral Valve Transcatheter Edge\u2010to\u2010Edge Repair"],"prefix":"10.1111","volume":"42","author":[{"given":"Kaho","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology Tokai University School of Medicine Isehara Kanagawa 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Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology Tokai University School of Medicine Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology Tokai University School of Medicine Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology Tokai University School of Medicine Isehara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Cardiology Tokai University 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