{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:42:55Z","timestamp":1787312575274,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["407655\/2012\u20103"],"award-info":[{"award-number":["407655\/2012\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["421843\/2017\u20109"],"award-info":[{"award-number":["421843\/2017\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305088\/2013\u20100"],"award-info":[{"award-number":["305088\/2013\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Patients with chronic Chagas cardiomyopathy (CCC) have a high mortality due to heart failure (HF). The aim of this study was to investigate clinical and echocardiographic predictors of incident HF in patients with CCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Single\u2010center retrospective longitudinal observational study which included 176 adult patients (59.1% women; 53.9\u00a0\u00b1\u00a010 years old; mean left ventricular [LV] ejection fraction 62%\u00a0\u00b1\u00a010%) at an early stage of CCC (electrocardiogram and\/or wall motion changes but no HF). The primary outcome was incident HF. The association between studied parameters with incident HF was performed by competing\u2010risk survival regression models using the Fine and Gray method.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After a mean follow\u2010up of 8.8\u00a0\u00b1\u00a03.6 years, 42 patients progressed to HF (27.04 cases\/1000 patient\u2010years). A model 0 adjusted for clinical and 2D\u2010Doppler echocardiographic parameters and for all\u2010cause mortality revealed diabetes mellitus (HR 4.91, 95% CI 1.67\u201314.4,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004), LV ejection fraction (HR 0.96, 95% CI 0.93\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022), and E\u2019 velocity (HR 0.79, 95% CI 0.67\u20130.95,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01) as independently associated with incident HF. The addition of strain\u2010derived parameters to model 0 revealed that LV global circumferential strain (HR 0.83, 95% CI 0.78\u20130.89,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and left atrial booster contraction strain (HR 1.14, 95% CI 1.02\u20131.28,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022) were associated with incident HF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While most clinical parameters were not associated with incident HF in patients with CCC, echocardiographic parameters, including LV systolic and diastolic function and strain\u2010derived parameters, were associated with incident HF in patients with CCC. This knowledge can be very useful for planning the care and follow\u2010up of these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70163","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T13:34:32Z","timestamp":1745847272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictors of Incident Heart Failure in Patients With Chronic Chagas Disease Cardiomyopathy"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2250-9214","authenticated-orcid":false,"given":"Danton Machado da","family":"Cunha","sequence":"first","affiliation":[{"name":"Antonio Pedro University Hospital Fluminense Federal University  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-3631","authenticated-orcid":false,"given":"Mauro Felippe 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6618-3397","authenticated-orcid":false,"given":"Danilo Bento","family":"Diogo","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory in Chagas Disease Evandro Chagas National Institute of Infectious Diseases Oswaldo Cruz Foundation  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5948-6282","authenticated-orcid":false,"given":"Luiz Henrique Conde","family":"Sangenis","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory in Chagas Disease Evandro Chagas National Institute of Infectious Diseases Oswaldo Cruz Foundation  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-6555","authenticated-orcid":false,"given":"Henrique 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