{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:51:10Z","timestamp":1781074270989,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017511","name":"Metro North Hospital and Health Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017511","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whilst females have relatively greater preservation of left ventricular ejection fraction (LVEF) following myocardial infarction (MI), they have higher rates of heart failure, presumably due to diastolic dysfunction (DD). This study sought to assess sex differences in LV diastolic function on Doppler echocardiography following MI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on 2505 consecutive patients with a first\u2010ever MI (defined using the Universal Definition of MI) between 2013 and 2020 were included. Echocardiography was performed within 24\u00a0h of admission. Significant DD was defined as grade 2\u00a0+\u00a03 DD according to current ASE\/EACVI guidelines. Diastolic function score (DFS) was calculated by summing the number of abnormal parameters out of the four key diastolic parameters (e\u2032 velocity, E\/e\u2032 ratio, left atrial volume index [LAVI], and tricuspid regurgitation velocity [TRV]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to males, females were older, had greater co\u2010morbidity, less 3\u2010vessel disease, higher LVEF (55.0\u00a0+\u00a09.8% vs. 52.7\u00a0\u00b1\u00a09.8%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and a greater proportion with LVEF\u00a0&gt;\u00a050% (74.4% vs. 66.2%, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). On group comparisons between sexes, LAVI, e\u2032 velocity, E\/e\u2032 ratio, significant DD, and DFS showed greater abnormalities in females. In multivariable models incorporating clinical, angiographic and echocardiographic data to determine independent predictors of diastolic parameters, female sex was independently associated with abnormal LAVI (OR 1.40, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.017), E\/e\u2032 ratio (OR 2.86, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), TRV (OR 1.88, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004), significant DD (OR 2.12, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and DFS (OR 2.59, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Female sex is a strong independent predictor of DD on Doppler echocardiography in patients with a first\u2010ever MI. This may explain the higher incidence of heart failure despite relatively preserved LVEF in females following MI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.70164","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T18:41:11Z","timestamp":1744396871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sex Differences in Diastolic Function Following Myocardial Infarction on Doppler Echocardiography"],"prefix":"10.1111","volume":"42","author":[{"given":"Nicole Ivy","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Cardiology Royal Brisbane and Women's Hospital, Herston  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Atherton","sequence":"additional","affiliation":[{"name":"Department of Cardiology Royal Brisbane and Women's Hospital, Herston  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liza","family":"Thomas","sequence":"additional","affiliation":[{"name":"Westmead Hospital University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian","family":"Whalley","sequence":"additional","affiliation":[{"name":"Dunedin School of Medicine University of Otago  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Cardiology Royal Brisbane and Women's Hospital, Herston  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mallouhi","sequence":"additional","affiliation":[{"name":"Statewide Cardiac Network Ministry of Health  Bowen Hills Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Vollbon","sequence":"additional","affiliation":[{"name":"Statewide Cardiac Network Ministry of Health  Bowen Hills Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhir B.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Royal Brisbane and Women's Hospital, Herston  Brisbane Queensland Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Australia"},{"name":"Faculty of Medicine and Dentistry Griffith University  Gold Coast Queensland 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