{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T17:10:31Z","timestamp":1754154631828,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study is the first attempt to apply shear wave elastography (SWE) technology to the dynamic evaluation of patients with chronic kidney disease (CKD), aiming to fill the evidence gap of this technology in this clinical scenario.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2010control study enrolled 75 biopsy\u2010confirmed CKD patients (observation group) and 20 healthy adults (control group). Renal morphological parameters (length, diameter, parenchymal thickness) were obtained via two\u2010dimensional ultrasonography. Under SWE mode, three consecutive measurements of Young's modulus (Emean, Emax, Emin) were performed at the right renal lower pole cortex, with the mean value used for analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Key findings included: Significant reductions in renal length (9.8\u00b11.2\u00a0cm vs. 11.5\u00b10.9\u00a0cm, <jats:italic>p<\/jats:italic> &lt; 0.05) and parenchymal thickness (1.2\u00b10.3\u00a0cm vs. 1.8\u00b10.2\u00a0cm, <jats:italic>p<\/jats:italic> &lt; 0.05) in CKD patients versus controls; Elevated elasticity parameters in CKD group (Emean: 24.7\u00b15.1\u00a0kPa vs. 12.3\u00b12.8\u00a0kPa; Emax: 38.9\u00b17.2\u00a0kPa vs. 16.1\u00b13.5\u00a0kPa; Emin: 15.2\u00b13.8\u00a0kPa vs. 8.7\u00b11.9\u00a0kPa; all <jats:italic>p<\/jats:italic> &lt; 0.05); Stage\u2010dependent variations: CKD Stage 3\u20134 exhibited 32% higher Emean than Stage 1\u20132 (<jats:italic>p<\/jats:italic> &lt; 0.01); Diagnostic performance metrics: Emax showed superior specificity (92.1%\u00a0vs. 85.6% for Emean, 78.3% for Emin), Emin demonstrated higher sensitivity (89.4%\u00a0vs. 82.7% for Emax, 79.5% for Emean); Strong correlations between SWE parameters and disease progression (<jats:italic>r<\/jats:italic> = 0.82 for Emax vs. eGFR, <jats:italic>P<\/jats:italic>&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SWE provides a reliable non\u2010invasive approach for quantifying renal elasticity alterations, demonstrating excellent diagnostic accuracy in CKD staging. The complementary performance of Emax (specificity) and Emin (sensitivity) suggests their combined use could optimize clinical decision\u2010making.<\/jats:p><\/jats:sec>","DOI":"10.1111\/echo.70231","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T11:43:18Z","timestamp":1750851798000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Application Value and Clinical Correlation of Ultrasonic Shear Wave Elastography in Chronic Kidney Disease"],"prefix":"10.1111","volume":"42","author":[{"given":"Li","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of HeBei University  Baoding Hebei China"},{"name":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province  Baoding Hebei 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Chronic Kidney Disease of Hebei Province  Baoding Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Diagnostic Affiliated Hospital of HeBei University  Baoding Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nephrology Affiliated Hospital of HeBei University  Baoding Hebei China"},{"name":"Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province  Baoding Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Xi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition Affiliated Hospital of HeBei University  Baoding Hebei 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