{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:57:38Z","timestamp":1785455858559,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer therapy\u2010related cardiac dysfunction (CTRCD) remains a critical limitation of cancer therapy, with implications for morbidity and survivorship. Echocardiography is an established surveillance tool, while electrocardiography (ECG) may offer earlier, low\u2010cost detection of subclinical cardiotoxicity. The relative diagnostic yield of these modalities is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To systematically review and compare echocardiography and ECG for early detection of CTRCD in patients receiving cancer therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following PRISMA 2020 guidelines, PubMed, Embase, Scopus, and CENTRAL were searched through May 2025. Eligible studies included prospective or retrospective cohorts reporting echocardiographic and ECG outcomes in adults undergoing chemotherapy. Data on left ventricular ejection fraction (LVEF), diastolic function, global longitudinal strain (GLS), and ECG abnormalities were extracted. Pooled incidence and effect estimates were calculated using random\u2010effects models. Risk of bias was assessed with QUADAS\u20102.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen cohort studies involving 1440 patients were included. The pooled incidence of echo\u2010defined CTRCD was 10% (95% confidence interval [CI] 7%\u201316%), with higher rates among anthracycline\u2010treated cohorts. Diastolic dysfunction and GLS reduction occurred in up to 40% of patients, frequently preceding a decline in LVEF. ECG abnormalities were observed in 35% (95% CI 22%\u201349%), most commonly QTc prolongation, ST\u2013T changes, fragmented QRS, and atrial fibrillation. Routine ECG demonstrated low sensitivity compared with echocardiography, though continuous monitoring and AI\u2010enhanced ECG showed potential for earlier detection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Echocardiography remains the cornerstone for CTRCD surveillance, with GLS and diastolic indices providing early warning. ECG abnormalities are frequent but inconsistent predictors; their role may expand with continuous and AI\u2010based approaches. A multimodal surveillance strategy integrating echo and advanced ECG may improve cardio\u2010oncology care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70331","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:04:39Z","timestamp":1762621479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["\u201cElectrocardiographic and Echocardiographic Monitoring for Early Chemotherapy\u2010Induced Cardiotoxicity: A Systematic Review and Meta\u2010Analysis\u201d"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4100-6271","authenticated-orcid":false,"given":"Param Darpan","family":"Sheth","sequence":"first","affiliation":[{"name":"Department of General Medicine JSS Medical College, JSS Academy of Higher Education and Research  Mysuru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9193-9805","authenticated-orcid":false,"given":"Chandana","family":"Srinath","sequence":"additional","affiliation":[{"name":"Department of General Medicine JSS Medical College, JSS Academy of Higher Education and Research  Mysuru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4323-470X","authenticated-orcid":false,"given":"Prasad","family":"Mayagondanahallay Chandrashekaraiah","sequence":"additional","affiliation":[{"name":"Department of General Medicine JSS Medical College, JSS Academy of Higher Education and Research  Mysuru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1983-2455","authenticated-orcid":false,"given":"Radha Wajapey","family":"Madhukar","sequence":"additional","affiliation":[{"name":"Department of General Medicine JSS Medical College, JSS Academy of Higher Education and Research  Mysuru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8710-2397","authenticated-orcid":false,"given":"Manjappa","family":"Mahadevappa","sequence":"additional","affiliation":[{"name":"Department of Cardiology JSS Medical College, JSS Academy of Higher Education and Research  Mysuru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13133714"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpt.2024.04.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1236966"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.20.00924"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6653971"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2024.101336"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2012.28549"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43044\u2010023\u201000331\u2010y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9817081"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1052699"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijh.ijh_4_19"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001813\u2010200301000\u201000010"},{"issue":"2","key":"e_1_2_10_15_1","article-title":"Speckle Tracking Echocardiography for Detection of Early Myocardial Changes in Patients Treated with Anthracyclines","volume":"11","author":"Mirzaee F.","year":"2017","journal-title":"International Cardiovascular Research Journal"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.21608\/svuijm.2024.254703.1755"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v19i1.40"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40880\u2010018\u20100343\u20107"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim\u20102022\u2010002339"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.10.2746"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds130"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.116.005521"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.2162"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a015273"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.06.011"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.23736\/S2724\u20105683.24.06614\u20106"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd10040175"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.70.5400"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010018\u20100240\u20102"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70331","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.70331","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:58:56Z","timestamp":1785452336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.70331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/echo.70331"],"URL":"https:\/\/doi.org\/10.1111\/echo.70331","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.175832290.07623253\/v1","asserted-by":"object"}]},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70331"}}