{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:57:37Z","timestamp":1785455857588,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to determine whether left atrial (LA) strain can identify early alterations in LA function in diffuse large B\u2010cell lymphoma (DLBCL) patients treated with R\u2010CHOP chemotherapy regimen and whether these alterations can prospectively predict the subsequent development of cancer therapy\u2013related cardiac dysfunction (CTRCD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>DLBCL patients scheduled to receive the R\u2010CHOP regimen were prospectively recruited for this study. Echocardiography was performed at T0 (pre\u2010chemotherapy), T1 (after the third cycle), T2 (end of 6\u20138 cycles), and T3 (1\u2010year post\u2010T2). Left ventricular global longitudinal strain (LV GLS), LA reservoir strain (LASr), LA conduit strain (LAScd), LA contraction strain (LASct), and LA stiffness index (LASI) were calculated using speckle tracking echocardiography (STE). Patients were divided into CTRCD and non\u2010CTRCD groups based on a &gt; 15% reduction in LV GLS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventeen patients (23.6%) developed to CTRCD after chemotherapy. Patients who developed CTRCD were relatively older (67 [57\u201371] vs. 60 [49\u201368],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). A significant deterioration in LASr, LAScd, and LASI at T1 persisted throughout the follow\u2010up period. Relative changes in LASr (\u2265 23.4%) and LASI (\u2265 20.0%) were robust predictors of subsequent CTRCD development. The LASr &gt; 35% criterion in the validation cohort demonstrated substantial agreement with the 2016 ASE guidelines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LASr and LASI effectively identify early alterations in LA function in DLBCL patients. Relative changes in LASr and LASI are robust predictors of subsequent CTRCD development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70339","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T17:59:11Z","timestamp":1762538351000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Left Atrial Function in Patients With Diffuse Large B\u2010Cell Lymphoma Treated With R\u2010CHOP Chemotherapy Regimen: A Speckle Tracking Echocardiographic Study"],"prefix":"10.1111","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5537-6724","authenticated-orcid":false,"given":"Baozhen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Cangzhou People's Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound 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