{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:44:47Z","timestamp":1790912687592,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Right ventricular\u2013pulmonary artery (RVPA) coupling is an emerging prognostic marker in cardiovascular disease, but its predictive value in patients undergoing mitral transcatheter edge\u2010to\u2010edge repair (MTEER) remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systematic review and meta\u2010analysis following PRISMA 2020 guidelines. PubMed, Scopus, and Web of Science were searched for studies evaluating the prognostic impact of RVPA coupling in patients undergoing MTEER, using tricuspid annular plane systolic excursion (TAPSE)\/pulmonary artery systolic pressure (PASP) or related markers. Risk of bias was assessed with the ROBINS\u2010I tool, and meta\u2010analyses were used to evaluate associations with clinical outcomes, including all\u2010cause mortality, major adverse cardiovascular events (MACE), and residual mitral regurgitation (MR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine studies involving 3281 patients were included. Baseline RVPA uncoupling was significantly associated with an increased incidence of MACE (risk ratio [RR] 1.75, 95% confidence interval [CI]: 1.40\u20132.19) and higher all\u2010cause mortality (RR 1.82, 95% CI: 1.53\u20132.18). No significant association was observed with post\u2010operative MR (RR 1.17, 95% CI: 0.83\u20131.63). Sensitivity analyses did not alter the direction of the findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RVPA uncoupling is associated with adverse outcomes after MTEER. Routine assessment may improve pre\u2010procedural risk stratification. Further studies should refine diagnostic thresholds and evaluate potential therapeutic strategies in the setting of impaired RVPA coupling prior to MTEER.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70387","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:25:19Z","timestamp":1768292719000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Right Ventricular\u2013Pulmonary Artery Coupling and Clinical Outcomes Following Mitral Transcatheter Edge\u2010to\u2010Edge Repair: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"43","author":[{"given":"Panagiotis","family":"Theofilis","sequence":"first","affiliation":[{"name":"1st Department of Cardiology \u201cHippokration\u201d General Hospital of Athens  Athens 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