{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T03:10:31Z","timestamp":1776309031040,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac involvement in systemic lupus erythematosus (SLE) is often subclinical and underdiagnosed. Although impaired global longitudinal strain (GLS) is well documented in SLE, data on layer\u2010specific myocardial deformation are scarce. This study aimed to assess left and right ventricular function in SLE patients using speckle tracking echocardiography (STE), focusing on layer\u2010specific LV strain and its association with disease activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included 43 SLE patients and 40 age\u2010 and sex\u2010matched healthy controls in a cross\u2010sectional design. All subjects underwent conventional transthoracic echocardiography and STE. Global longitudinal strain (GLS) of the left ventricle (LV) was measured separately for endocardial, mid\u2010myocardial, and epicardial layers. Right ventricular (RV) free wall strain was also assessed. Correlation between strain parameters and SLEDAI\u20102K score was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      While conventional echocardiographic parameters, including LV ejection fraction, were similar between groups, STE revealed significant myocardial impairment in SLE patients. LV endocardial and mid\u2010myocardial GLS were significantly reduced in SLE patients compared to controls (\u201315.7% vs. \u201320.3% and \u201318.1% vs. \u201320.1%, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Epicardial strain showed a nonsignificant reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0 = \u00a00.081). RV free wall strain was also lower in SLE patients (\u201326.1% vs. \u201329.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0 = \u00a00.001). LV endocardial strain strongly correlated with SLEDAI\u20102K (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      = 0.716,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), while RV strain did not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>STE detects early biventricular myocardial involvement in SLE, with evidence of systolic dysfunction predominantly at the LV endocardial level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70402","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:48:07Z","timestamp":1772988487000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Layer\u2010Specific Strain Analysis for Detecting Subclinical Cardiac Dysfunction in Systemic Lupus Erythematosus"],"prefix":"10.1111","volume":"43","author":[{"given":"Mert","family":"G\u00fcrsoy","sequence":"first","affiliation":[{"name":"Cerrahpasa Institute of Cardiology Department of Cardiology Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Kaz\u0131m Ersanl\u0131","sequence":"additional","affiliation":[{"name":"Cerrahpasa Institute of Cardiology Department of Cardiology Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan Ali","family":"Barman","sequence":"additional","affiliation":[{"name":"Cerrahpasa Institute of Cardiology Department of Cardiology Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Cerrahpasa Institute of Cardiology Department of Cardiology Istanbul University\u2010Cerrahpasa  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-23488-0_12"},{"key":"e_1_2_10_3_1","first-page":"476","volume-title":"EULAR Textbook of Rheumatic Diseases","author":"George B.","year":"2012"},{"key":"e_1_2_10_4_1","volume-title":"Non\u2010Coronary Cardiac Manifestations of Systemic Lupus Erythematosus in Adults","author":"Costenbader K. H.","year":"2024"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.109.862334"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2023.08.142"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.122.014419"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-20-859"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"75","article-title":"Early Assessment of Right Ventricular Function in Systemic Lupus Erythematosus Patients Using Strain and Strain Rate Imaging","volume":"111","author":"Luo R.","year":"2018","journal-title":"Arquivos Brasileiros De Cardiologia"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"288","article-title":"Systemic Lupus Erythematosus Disease Activity Index 2000","volume":"29","author":"Gladman D. D.","year":"2002","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-020-01816-6"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.04.018"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.038"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203314"},{"key":"e_1_2_10_16_1","first-page":"57","article-title":"Mechanics of Early Ventricular Impairment in Systemic Sclerosis and the Effects of Peripheral Arterial Haemodynamics","volume":"37","author":"Tountas C.","year":"2018","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu.2013.2066.181.zdr"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa050"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.02.015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2025.07.007"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.12515"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2013.07.011"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2018.11.001"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090043"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2019.12.033"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2018.09.002"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.70402","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:06:23Z","timestamp":1773025583000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.70402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1111\/echo.70402"],"URL":"https:\/\/doi.org\/10.1111\/echo.70402","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-11-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70402"}}