{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T11:55:00Z","timestamp":1776254100006,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Chagas cardiomyopathy (CC) is characterized by progressive myocardial fibrosis, contractile dysfunction, and structural remodeling. Strain imaging (SI) holds promise for detecting early myocardial impairment, but its utility in tracking CC progression remains unclear. This study evaluated SI's clinical utility across the CC spectrum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, 79 adults with serologically confirmed Chagas disease underwent myocardial strain assessment using equipment from General Electric (GE) or Philips (PH). Strain parameters, including global longitudinal strain (GLS), and segmental longitudinal strain (SLS), were analyzed across four CC stages (A, B1, B2, and C), stratified by fibrosis severity via late gadolinium enhancement (LGE) on cardiac magnetic resonance. Spearman coefficients assessed correlations between strain and fibrosis burden. Lin's concordance index evaluated inter\u2010vendor agreement. Diagnostic performance for fibrosis detection was quantified using area under the receiver operating characteristic curve (AUC), with strain abnormalities defined by ROC\u2010derived median cut\u2010offs.<\/jats:p>\n                    <jats:p>\n                      GLS declined progressively with advancing CC stage across both vendors, though correlations with fibrosis percentage were weak (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      &lt; 0.30). SLS abnormalities were present in Stage A patients despite absence of LGE\u2010detected fibrosis. SLS showed moderate accuracy in localizing, but not quantifying, fibrosis (mean AUC: 0.72 \u00b1 0.11). Inter\u2010vendor concordance was limited for GLS (Lin's index: 0.80) and SLS (range: 0.20\u20130.70).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SI reveals early myocardial dysfunction in Chagas patients, even in the absence of detectable fibrosis, suggesting a subclinical continuum of disease. However, the modest correlation with fibrosis burden and substantial inter\u2010vendor variability underscore the need for vendor\u2010specific calibration and caution in clinical interpretation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70417","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:01:46Z","timestamp":1773241306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Echocardiographic Strain Analysis Compared With Assessment of Fibrosis by Cardiac Magnetic Resonance in the Evaluation of Chagas Cardiomyopathy"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-5509","authenticated-orcid":false,"given":"Laura Marcela","family":"Romero\u2010Acero","sequence":"first","affiliation":[{"name":"Cardiology Division Cardiac Care and Vascular Medicine \/ Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sridhar","family":"Mangalesh","sequence":"additional","affiliation":[{"name":"Department of Medicine Jacobi Medical Center Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Nanna","sequence":"additional","affiliation":[{"name":"Cardiology Division Cardiac Care and Vascular Medicine \/ Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Medina\u2010Mur","sequence":"additional","affiliation":[{"name":"Cardiology Department Universidad Del Bosque La Cardio\u2010Fundaci\u00f3n Cardio\u2010Infantil  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frida T","family":"Manrique Espinel","sequence":"additional","affiliation":[{"name":"Internal Medicine\u2010 Cardiology Section, Fundacion Santafe de Bogota  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosangela Casanova","family":"Libreros","sequence":"additional","affiliation":[{"name":"Research Department Hospital De San Jos\u00e9 Fundaci\u00f3n Universitaria de Ciencias de La Salud\u2010FUCS  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres\u2010D Gallego","family":"Ardila","sequence":"additional","affiliation":[{"name":"Research Department Hospital De San Jos\u00e9 Fundaci\u00f3n Universitaria de Ciencias de La Salud\u2010FUCS  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor M.","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Texas Heart Institute Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Scearresi","sequence":"additional","affiliation":[{"name":"Cardiology Department. Instituto de Cardiolog\u00eda San Nicolas  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Felipe","family":"V\u00e1squez\u2010Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Cardiology Non\u2010Invasive Cardiology\u2014Echocardiography Laboratory. Fundacion Cardioinfantil\u2014LaCardio  Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Salazar","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Cardiology Non\u2010Invasive Cardiology\u2014Echocardiography Laboratory. Fundacion Cardioinfantil\u2014LaCardio  Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian F.","family":"Forero","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Cardioinfantil\u2010Instituto de Cardiolog\u00eda Universidad Del Rosario  Bogot\u00e1 Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Lombo","sequence":"additional","affiliation":[{"name":"Cardiology Department Yale School of Medicine Yale University  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni J","family":"Nanna","sequence":"additional","affiliation":[{"name":"Department of Medicine Zucker School of Medicine, Hofstra University  Hempstead New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuan\u2010Yu","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Medicine Jacobi Medical Center Albert Einstein College of Medicine  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