{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:43:12Z","timestamp":1776433392230,"version":"3.51.2"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Backgroud<\/jats:title>\n                    <jats:p>Non\u2010invasive assessment of pulmonary arterial pressure is critical in managing pulmonary hypertension due to left heart disease (PH\u2010LHD). The curvature of the interventricular septum (IVS) reflects right ventricular pressure overload. We propose a novel echocardiographic metric\u2014interventricular septal eccentric area (ISEA)\u2014to quantify IVS curvature and evaluate its diagnostic value in PH\u2010LHD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed patients with PH\u2010LHD confirmed by right heart catheterization (RHC) and individuals with normal pulmonary pressure as controls. ISEA and pulmonary artery systolic pressure (PASP) were measured by echocardiography. Correlations with mean pulmonary arterial pressure (mPAP) and mean pulmonary capillary wedge pressure (mPCWP) were assessed. Logistic regression and receiver operating characteristic (ROC) analyses evaluated the predictive value of ISEA for different mPAP thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ISEA was significantly higher in PH\u2010LHD patients than controls and correlated with mPAP (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.650) and mPCWP (\n                      <jats:italic>r<\/jats:italic>\n                      = 0.544) (both\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). ISEA values were greater in patients with mPAP \u226535\u00a0mmHg than in those with 20\u201335\u00a0mmHg, but not between \u226545 and 35\u201344\u00a0mmHg. HFrEF patients had higher mPAP and ISEA than HFpEF patients. ISEA predicted mPAP &gt;20, \u226535, and \u226545\u00a0mmHg with AUCs of 0.817, 0.842, and 0.822, respectively. Combining ISEA with PASP improved diagnostic performance compared to PASP alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ISEA is a promising non\u2010invasive marker for pulmonary pressure in PH\u2010LHD and may enhance the diagnostic accuracy of conventional echocardiographic measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70436","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:58:26Z","timestamp":1775217506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Quantification Method for Ventricular Septal Curvature in Pulmonary Hypertension Associated With Left Heart Disease"],"prefix":"10.1111","volume":"43","author":[{"given":"Yuan","family":"Tian","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2013Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun\u2010Lu","family":"Huang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2013Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2013Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ding","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2013Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Tse","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2013Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Department of Health Sciences School of Nursing and Health Studies Hong Kong Metropolitan University  Hong Kong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua\u2010Ying","family":"Fu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2013Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2013Molecular Function of Cardiovascular Disease Department of Cardiology Tianjin Institute of Cardiology Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00003912"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2017.18.6.888"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.1.68"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00596.2016"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081970"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pul2.12216"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2021.11.007"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01683-4"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2018180120"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-020-00643-x"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2013.1324"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1269"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0277"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.70436","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:47:39Z","timestamp":1776430059000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.70436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1111\/echo.70436"],"URL":"https:\/\/doi.org\/10.1111\/echo.70436","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"2026-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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