{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:43:08Z","timestamp":1776433388345,"version":"3.51.2"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515140149"],"award-info":[{"award-number":["2023A1515140149"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This investigation delineates ventricular adaptive patterns across clinical subtypes of fetal growth restriction (FGR) using fetal heart quantification (fetal HQ) technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between June 2021 and June 2022, 30 singleton FGR pregnancies (16 early\u2010onset, 14 late\u2010onset) and 60 normal controls were enrolled, according to the inclusion and exclusion criteria. Data collected included maternal\u2010fetal parameters, fetal biometry, and Doppler indices. Standard dynamic four\u2010chamber views were analyzed offline using fetal HQ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both FGR groups delivered earlier and had lower birth weights than controls (both\n                      <jats:italic>p<\/jats:italic>\n                      \u02c2 0.05). Myocardial performance index was elevated in FGR fetuses. Left ventricle (LV) global longitudinal strain (GLS) and fractional area change (FAC) were reduced in both early\u2010 and late\u2010onset FGR compared to controls (GLS: \u221222% \u00b1 5%\u00a0vs. \u221227% \u00b1 4%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001; \u221223% \u00b1 5%\u00a0vs. \u221227%\u00b14%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.020; FAC: 0.43 \u00b1 0.06\u00a0vs. 0.50 \u00b1 0.06,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002; 0.44 \u00b1 0.08\u00a0vs. 0.50 \u00b1 0.06,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.022). Right ventricle (RV) FAC was also lower in both FGR groups (0.36 \u00b1 0.09\u00a0vs. 0.42 \u00b1 0.06,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.028; 0.33 \u00b1 0.13\u00a0vs. 0.42 \u00b1 0.06,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). Fractional shortening (FS) was impaired in RV selected segments in early\u2010onset FGR and across most segments in late\u2010onset FGR (both\n                      <jats:italic>p<\/jats:italic>\n                      \u02c2 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GLS and FS detect subclinical ventricular dysfunction in FGR, with alterations in either parameter paralleling subsequent FAC modifications. The two clinical subtypes demonstrate distinct right ventricular adaptive patterns.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70438","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:45:46Z","timestamp":1775745946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Divergent Right Ventricular Adaptation in Fetal Growth Restriction Subtypes Revealed by Quantitative Cardiac Profiling"],"prefix":"10.1111","volume":"43","author":[{"given":"Tingting","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Fetal Medicine and Prenatal Diagnosis Zhujiang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2021.02.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.02.007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000000210"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0325906"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/0102\u2010311XPT231022"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004225"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i13.2855"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13699"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.577"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.05.003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1489534"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5805"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.5935\/abc.20140041"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2007.141002"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.105.571455"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15870"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17505"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm\u20102020\u20100246"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20854"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild\u20102013\u2010305923"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20272"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109378(85)90298\u20104"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23698"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X18666211227145856"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1959"},{"key":"e_1_2_11_27_1","doi-asserted-by":"crossref","unstructured":"A.NawatheandC.Lees \u201cEarly Onset Fetal Growth Restriction \u201dBest Practice & Research. 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