{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:43:12Z","timestamp":1776433392974,"version":"3.51.2"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Cardiovascular disease (CVD) remains the leading cause of death among kidney transplant recipients (KTRs). Current guidelines recommend using left ventricular global longitudinal strain (GLS) for the early identification of cardiac dysfunction, but its value in KTRs has not been well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a single\u2010center retrospective cohort study of adult KTRs who underwent KT between January 2015 and January 2024 and had an adequate\u2010quality pre\u2010transplant echocardiogram. Patients without follow\u2010up at our institution or with atrial fibrillation were excluded. GLS was measured using vendor\u2010independent two\u2010dimensional speckle\u2010tracking software, with abnormal GLS defined as absolute GLS &lt;\u00a016% (lower absolute strain magnitude), with higher values indicating better systolic function. Patients were divided into normal GLS (NGLS) or abnormal GLS (AbGLS) groups. The primary outcome was major adverse cardiovascular events (MACE), defined as cardiovascular death, acute coronary syndrome, stroke, hospitalization for heart failure, or major arrhythmia. Kaplan\u2013Meier survival curves and Cox proportional hazards models were constructed for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 518 screened KTRs, 341 met the study criteria. Compared with NGLS patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 159), AbGLS patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 182) were older (55.1\u00a0vs. 51.5 years) and had a significantly higher prevalence of hypertension, diabetes mellitus, and coronary artery disease. Over a mean follow\u2010up of 52.7 \u00b1 28.3 months, Kaplan\u2013Meier analysis demonstrated a significantly higher cumulative incidence of MACE in the AbGLS group, with a 5\u2010year incidence of 27.1% versus 9.4% in NGLS (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002). In multivariable Cox regression adjusted for confounding variables identified from univariate regression, GLS was independently associated with MACE (adjusted HR 0.94; 95% CI 0.88\u20131.00;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04), whereas left ventricular ejection fraction was not.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this retrospective single\u2010center study, GLS was independently associated with MACE in KTRs, supporting a potential role for GLS in cardiovascular risk assessment in KT candidates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70457","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T10:10:12Z","timestamp":1776161412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Pre\u2010Transplant Left Ventricular Longitudinal Strain With Long\u2010Term Cardiovascular Outcomes Following Kidney Transplantation"],"prefix":"10.1111","volume":"43","author":[{"given":"Zalan","family":"Shah","sequence":"first","affiliation":[{"name":"Saint Louis University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ava","family":"Delonais\u2010Parker","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqing","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine SSM Health \u2010 Saint Louis University Hospital  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Heuer","sequence":"additional","affiliation":[{"name":"Saint Louis University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rushda Faruk","family":"Mansuri","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, College For Public Health and Social Justice Saint Louis University  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista L.","family":"Lentine","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Internal Medicine SSM Health \u2010 Saint Louis University Hospital  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina M.","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine SSM Health \u2010 Saint Louis University Hospital  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"SLU Transplant Rx research 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