{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:43:16Z","timestamp":1786293796094,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Describe longitudinal echocardiographic changes during the first year of life in infants with bronchopulmonary dysplasia (BPD)\u2013associated pulmonary hypertension (PH) and assess the prognostic value of early echocardiographic parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a prospective longitudinal cohort study. Preterm infants with BPD underwent echocardiographic screening at 28\u00a0days of life\u00a0and, if diagnosed with PH, were followed every 3\u00a0months until 12\u00a0months or death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the first year of life, 40.9% of infants died, 52.3% survived with complete resolution of PH, and 6.8% survived with persistent mild PH. Severe BPD was significantly more prevalent among non\u2010survivors. At the 28\u2010day of life echocardiographic assessment, survivors exhibited higher tricuspid annular plane systolic excursion (8.67\u00a0vs. 7.45\u00a0mm) and lower left ventricular eccentricity index (1.05\u00a0vs. 1.30), whereas tricuspid regurgitation gradient and pulmonary artery acceleration time did not differ significantly. Serial echocardiography showed a consistent trend toward improvement in pulmonary artery acceleration time, left ventricular eccentricity index and tricuspid annular plane systolic excursion, suggesting a reduction in pulmonary vascular resistance and maturation of right ventricular systolic function. Receiver operating characteristic analysis showed that tricuspid annular plane systolic excursion at 28 days had modest discriminatory ability for predicting 1\u2010year survival, with a cutoff value of 7.14\u00a0mm associated with improved survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In infants with BPD\u2013associated PH, echocardiographic abnormalities frequently improve over time among survivors. Longitudinal echocardiographic assessment may aid early risk stratification, with tricuspid annular plane systolic excursion providing supportive prognostic information when interpreted in conjunction with other echocardiographic parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70504","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:32:51Z","timestamp":1778848371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Echocardiographic Evaluation of Pulmonary Hypertension Trajectories in Infants With Bronchopulmonary Dysplasia"],"prefix":"10.1111","volume":"43","author":[{"given":"Viet Tung","family":"Cao","sequence":"first","affiliation":[{"name":"Heart Center Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Van Dang","sequence":"additional","affiliation":[{"name":"Heart Center Vietnam National Children's Hospital  Hanoi Vietnam"},{"name":"Hanoi Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha Tu","family":"Le","sequence":"additional","affiliation":[{"name":"Heart Center Vietnam National Children's Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai Anh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Heart Center Vietnam National Children's Hospital  Hanoi Vietnam"},{"name":"Hanoi Medical University  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2016.255"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-021-02330-w"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.142.1MA2.187"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.07.035"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.06.022"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.05.029"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-021-01009-6"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000322006"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","unstructured":"N.Gali\u00e8 M.Humbert andJ. L.Vachiery \u201c2015 ESC\/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS):Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC) International Society for Heart and Lung Transplantation (ISHLT) \u201d (2016) 67\u2013119.","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24211"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-012-0520-4"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-018-0303-8"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318531"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-0971"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-20-192"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-547OC"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.113.000878"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.70504","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:26:08Z","timestamp":1786292768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.70504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/echo.70504"],"URL":"https:\/\/doi.org\/10.1111\/echo.70504","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2026-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70504"}}