{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:43:49Z","timestamp":1786293829514,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n Dasatinib, a tyrosine kinase inhibitor used to treat chronic myeloid leukemia (CML), is known to cause cardiopulmonary toxicities; however, little is known about the echocardiographic changes associated with this therapy. We present a comprehensive echocardiographic assessment of patients with CML on Dasatinib therapy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We performed a retrospective cohort analysis on adult patients with CML receiving Dasatinib between 2017 and 2023. Comprehensive clinical and echocardiographic data with speckle\u2010tracking analyses were included.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 199 patients with CML on Dasatinib, 75 (38%) patients had a pre\u2010Dasatinib echocardiogram, and 49 (25%) patients had both pre\u2010 and post\u2010Dasatinib echocardiograms. Among 44 patients with analyzable echocardiograms (average age 59\u00a0\u00b1\u00a015 years old, 39% female), 7 (16%) patients had baseline heart failure with preserved ejection fraction (HFpEF). After initiation of Dasatinib, there was a significant increase in left ventricular (LV) end\u2010diastolic diameter index (2.4 [2.2, 2.6] vs. 2.6 [2.4, 2.8]cm\/m\n 2<\/jats:sup>\n ,\n p<\/jats:italic>\n < 0.01), LV end\u2010systolic volume index (16 [13, 26] vs. 21 [14, 26] mL\/m\n 2<\/jats:sup>\n ,\n p<\/jats:italic>\n = 0.04) and LV mass index (85.3 [75.4, 94.4] vs. 93.1 [80.6, 114.7]g\/m\n 2<\/jats:sup>\n ,\n p<\/jats:italic>\n < 0.01). There was a significant increase in left atrial (LA) volume index (LAVI, 29.0\u00a0\u00b1\u00a010.6\u00a0vs. 33.4\u00a0\u00b1\u00a013.0\u00a0mL\/m\n 2<\/jats:sup>\n ,\n p<\/jats:italic>\n = 0.01), decrease in lateral e\u2019 velocity (11.8\u00a0\u00b1\u00a03.3\u00a0vs. 10.4\u00a0\u00b1\u00a02.8\u00a0cm\/sec,\n p<\/jats:italic>\n < 0.01) and increase in E\/e\u2019 (9.5\u00a0\u00b1\u00a02.8\u00a0vs. 10.7\u00a0\u00b1\u00a03.5,\n p<\/jats:italic>\n = 0.04) post\u2010Dasatinib. Among patients with abnormal LAVI post\u2010Dasatinib, higher LAVI correlated with worsened LA reservoir strain (\n r<\/jats:italic>\n = \u22120.59,\n p<\/jats:italic>\n = 0.01). LV ejection fraction and global longitudinal strain were not significantly changed. Patients with baseline HFpEF were significantly more likely to have progression in diastolic dysfunction compared to patients without HFpEF (\n p<\/jats:italic>\n = 0.03).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Dasatinib was associated with significant changes in LV structure, LA volume, and diastolic parameters in patients with CML. Patients with baseline HFpEF were more likely to progress in diastolic dysfunction on Dasatinib.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/echo.70517","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T10:39:41Z","timestamp":1779964781000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Echocardiographic Assessment of Patients With Chronic Myeloid Leukemia on Dasatinib"],"prefix":"10.1111","volume":"43","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medicine Northwestern Memorial Hospital Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinesh","family":"Appadurai","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paulina","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Division of Cardiology The University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Altman","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Northwestern Memorial Hospital Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nausheen","family":"Akhter","sequence":"additional","affiliation":[{"name":"Division of Cardiology Bluhm Cardiovascular Institute Northwestern Memorial Hospital Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.745525"},{"issue":"21","key":"e_1_2_10_3_1","first-page":"1","article-title":"United States Life Tables, 2006","volume":"58","author":"Arias 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