{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:25:05Z","timestamp":1786987505742,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,7]]},"abstract":"ABSTRACT<\/jats:title>\n \n Purpose<\/jats:title>\n Whether de novo organized left atrial tachyarrhythmia (LAT) shows preserved left atrial appendage (LAA) mechanics has not been adequately characterized. We compared LAA peak emptying velocity across atrial fibrillation (AF) phenotypes and de novo LAT.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Multicenter retrospective cohort of 634 consecutive first\u2010ablation candidates undergoing pre\u2010ablation transesophageal echocardiography (TEE) at five centers: paroxysmal AF (PAF,\n n<\/jats:italic>\n = 146), persistent AF (PeAF,\n n<\/jats:italic>\n = 310), long\u2010standing persistent AF (LsPeAF,\n n<\/jats:italic>\n = 86), and LAT (\n n<\/jats:italic>\n = 92). Markedly reduced LAA function was peak emptying velocity <25\u00a0cm\/s. Multivariable regression adjusted for rhythm during TEE, CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n \u2010VASc, body mass index (BMI), left ventricular ejection fraction (LVEF), and left atrial (LA) diameter.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Mean LAA velocity was 55.7\u00a0\u00b1\u00a019.4 (PAF), 44.3\u00a0\u00b1\u00a018.5 (PeAF), 31.0\u00a0\u00b1\u00a012.5 (LsPeAF), and 36.6\u00a0\u00b1\u00a013.5\u00a0cm\/s (LAT);\n p<\/jats:italic>\n \u00a0<\u00a00.001. LAT lay closer to LsPeAF than to PAF and did not differ from LsPeAF (Tukey\n p<\/jats:italic>\n = 0.140). Prevalence of velocity <25\u00a0cm\/s: 2.7%, 11.9%, 32.6% and 18.5% (\n p<\/jats:italic>\n \u00a0<\u00a00.001). After adjustment, larger LA diameter (\n \u03b2<\/jats:italic>\n = \u22120.53\/mm,\n p<\/jats:italic>\n \u00a0<\u00a00.001) and higher CHA\n 2<\/jats:sub>\n DS\n 2<\/jats:sub>\n \u2010VASc (\n \u03b2<\/jats:italic>\n = \u22121.93\/point,\n p<\/jats:italic>\n \u00a0<\u00a00.001) were independently associated with lower velocity. Compared with LAT, PAF had lower odds of velocity <25\u00a0cm\/s (OR 0.19, 95% CI 0.06\u20130.62).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n De novo organized LAT exhibits LAA mechanical dysfunction comparable to long\u2010standing persistent AF rather than to PAF. Organized rhythm does not imply preserved appendage function. LAA peak emptying velocity may serve as a functional remodeling marker for pre\u2010ablation phenotyping.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/echo.70545","type":"journal-article","created":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T17:36:15Z","timestamp":1783272975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Atrial Appendage Mechanical Dysfunction in De Novo Organized Left Atrial Tachyarrhythmia: A Multicenter Pre\u2010Ablation Study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-7811","authenticated-orcid":false,"given":"Maciej","family":"W\u00f3jcik","sequence":"first","affiliation":[{"name":"Department of Cardiology Medical University of Lublin Lublin Poland"},{"name":"Wojew\u00f3dzki Szpital Specjalistyczny w Bia\u0142ej Podlaskiej Bia\u0142a Podlaska Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"B\u0142aszkiewicz","sequence":"additional","affiliation":[{"name":"Wojew\u00f3dzki Szpital Specjalistyczny w Bia\u0142ej Podlaskiej Bia\u0142a Podlaska Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart\u0142omiej","family":"Bi\u0144kowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology Copernicus Memorial Hospital in \u0141\u00f3d\u017a, Comprehensive Cancer Center and Traumatology \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Kiliszek","sequence":"additional","affiliation":[{"name":"Military Institute of Medicine \u2010 National Research Institute Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Denysiuk","sequence":"additional","affiliation":[{"name":"Department of Cardiology Stefan Cardinal Wyszy\u0144ski Province Specialist Hospital Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Kucejko","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology and Arrhythmology, University Hospital No 2 Medical University of \u0141\u00f3d\u017a \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90644-0"},{"key":"e_1_2_9_3_1","first-page":"1059","article-title":"Spontaneous Echocardiographic Contrast: A Window Into the Left Atrial Appendage","volume":"7","author":"Abdelmoneim S. 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