{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:25:39Z","timestamp":1786987539375,"version":"build-2736575974"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transcatheter closure of ventricular septal defects (VSDs) has become a widely accepted alternative to surgical repair, owing to its high success rates and lower risk of complications. Advances in three\u2010dimensional (3D) echocardiography, including 3D speckle\u2010tracking and global longitudinal strain analysis, now allow for detailed assessment of ventricular performance and provide valuable insights into left ventricular remodeling following transcatheter VSD closure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study enrolled 56 children aged 2\u201316 years with congenital perimembranous or muscular VSD undergoing transcatheter device closure at Ain Shams University Hospitals, and 56 age\u2010 and sex\u2010matched healthy controls. 3D speckle\u2010tracking echocardiography (3D\u2010STE) was performed at baseline and at six\u2010month follow\u2010up to quantify global longitudinal (GLS), circumferential (GCS), and radial strain (GRS), alongside LV volumes and ejection fraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At six months, LV volumes showed no significant change; however, ventricular function improved significantly. Mean 3D ejection fraction improved from 55%\u00a0\u00b1\u00a04% preoperatively to 58%\u00a0\u00b1\u00a03% at six months (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), with parallel improvement in GLS, GCS, and GRS (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001). LV end\u2010diastolic and end\u2010systolic volumes did not change significantly at six months.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates a significant improvement in 3D echocardiography\u2013derived ejection fraction and global strain indices following transcatheter VSD closure, reflecting early favorable functional recovery and improved myocardial mechanics rather than complete structural reverse remodeling. These findings support transcatheter VSD closure as a safe and effective intervention with acceptable short\u2010term outcomes, though longer follow\u2010up is needed to determine whether volumetric reverse remodeling ensues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70552","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:32:01Z","timestamp":1784964721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Functional Recovery and Myocardial Deformation Improvement After Transcatheter VSD Closure: A 3D Speckle\u2010Tracking Echocardiography Study"],"prefix":"10.1111","volume":"43","author":[{"given":"Amira","family":"Nour","sequence":"first","affiliation":[{"name":"Cardiology department Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza Abdallah El","family":"Fiky","sequence":"additional","affiliation":[{"name":"Cardiology department Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norhan Abdelfattah","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Cardiology department Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"ALGhazawy","sequence":"additional","affiliation":[{"name":"Cardiology department Ain Shams University  Cairo Egypt"},{"name":"Department of medicine University of Connecticut School of medicine  Farmington Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Rashad","sequence":"additional","affiliation":[{"name":"Cardiology department Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-014-0144-2"},{"key":"e_1_2_10_3_1","first-page":"p298","volume-title":"Pediatric Cardiothoracic Surgery","author":"Mavroudis C.","year":"2003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.09.068"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa554"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-009-9147-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.112.972588"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43044-019-0001-7"},{"issue":"1","key":"e_1_2_10_9_1","article-title":"Assessment of Ventricular Septal Function After VSD Transcatheter Device Closure Using Speckle Tracking Technique","volume":"111","author":"Araby Hassan M.","year":"2018","journal-title":"QJM: An International Journal of Medicine"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2017.06.01"},{"issue":"12","key":"e_1_2_10_11_1","first-page":"1192","article-title":"Changes in Left Ventricular Systolic and Diastolic Function After Transcatheter Device Closure of Ventricular Septal Defects: Assessment by 2D and 3D Speckle Tracking Echocardiography","volume":"29","author":"Kharwar R. B.","year":"2016","journal-title":"Journal of the American Society of Echocardiography"},{"issue":"1","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4103\/HEARTVIEWS.HEARTVIEWS_13_19","article-title":"Transcatheter Device Closure of Perimembranous Ventricular Septal Defect in Pediatric Patients: Long\u2010term Outcomes","volume":"21","author":"Shah J. H.","year":"2020","journal-title":"Heart Views: The Official Journal of the Gulf Heart Association"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23575"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.08.082"},{"issue":"12","key":"e_1_2_10_15_1","first-page":"1092","article-title":"Management of the Arrhythmia Around the Procedure of Transcatheter Closure of Ventricular Septal Defects in Pediatric Patients","volume":"33","author":"Xie Y. M.","year":"2005","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi [Chinese Journal of Cardiovascular Diseases]"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70552","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.70552","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:24:10Z","timestamp":1786983850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.70552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/echo.70552"],"URL":"https:\/\/doi.org\/10.1111\/echo.70552","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70552"}}