{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:21:37Z","timestamp":1790785297643,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This commentary discusses the AVI\/LVGLS ratio as an emerging, fully non\u2010invasive marker of ventricular\u2013arterial coupling (VAC) for refining cardiovascular risk assessment in hypertension beyond conventional indices such as left ventricular ejection fraction and Ea\/Ees.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We critically appraised the study by Zhang et\u00a0al., which evaluated the association between the arterial velocity\u2010pulse index to left ventricular global longitudinal strain ratio and estimated 10\u2010year atherosclerotic cardiovascular disease (ASCVD) risk in hypertensive patients. The commentary integrates these findings with prior evidence on arterial stiffness, myocardial deformation, and VAC assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Zhang et\u00a0al. showed that AVI\/LVGLS differed significantly between hypertensive patients and normotensive controls and was independently associated with elevated estimated 10\u2010year ASCVD risk. An AVI\/LVGLS ratio below the fifth percentile predicted high ASCVD risk after multivariable adjustment, while the composite index demonstrated better discrimination than AVI, LVGLS, or conventional ventricular\u2013vascular index alone. These findings support the incremental value of combining vascular load and myocardial deformation into a single echocardiography\u2010compatible parameter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AVI\/LVGLS may provide a practical bridge between vascular and myocardial phenotyping in hypertension, offering a sensitive marker of maladaptive VAC and subclinical cardiovascular risk. Prospective, multicenter validation is required before implementation in routine risk stratification or therapeutic monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70558","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:16:55Z","timestamp":1783754215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Moving the Goalposts in Hypertensive Risk Assessment: The AVI\/LVGLS Ratio as a Sensitive Detector of Maladaptive Ventricular\u2013Arterial Coupling"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9165-7732","authenticated-orcid":false,"given":"Giancarlo","family":"Trimarchi","sequence":"first","affiliation":[{"name":"Interdisciplinary Center for Health Sciences Scuola Superiore Sant'Anna Pisa Italy"},{"name":"Ospedale Del Cuore \u201cG. Pasquinucci\u201d Fondazione Toscana Gabriele Monasterio  Massa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Pizzino","sequence":"additional","affiliation":[{"name":"Ospedale Del Cuore \u201cG. Pasquinucci\u201d Fondazione Toscana Gabriele Monasterio  Massa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Mariani","sequence":"additional","affiliation":[{"name":"Ospedale Del Cuore \u201cG. Pasquinucci\u201d Fondazione Toscana Gabriele Monasterio  Massa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010019\u20100244\u20102"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022367"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","unstructured":"S.Zhang J.Chen L.Yang et\u00a0al. \u201cAssociation of Echocardiographic Ventricular\u2013Arterial Coupling With Elevated 10\u2010Year ASCVD Risk in Hypertensive Patients \u201d (2026) Published online.","DOI":"10.1111\/echo.70547"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1436"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/08037051.2025.2457698"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13049"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.43125"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.08.011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcecho.jcecho_26_25"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2410282"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpaf113"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1460826"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3411"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd11080245"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.70558","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:24:12Z","timestamp":1786983852000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.70558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/echo.70558"],"URL":"https:\/\/doi.org\/10.1111\/echo.70558","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70558"}}