{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:21:23Z","timestamp":1787602883478,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/201.561\/2014"],"award-info":[{"award-number":["E\u201026\/201.561\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/110.176\/2014"],"award-info":[{"award-number":["E\u201026\/110.176\/2014"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["407655\/2012\u20103"],"award-info":[{"award-number":["407655\/2012\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["421843\/2017\u20109"],"award-info":[{"award-number":["421843\/2017\u20109"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305088\/2013\u20100"],"award-info":[{"award-number":["305088\/2013\u20100"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to evaluate the all\u2010cause mortality predictive value of left atrioventricular coupling indexes in patients with chronic Chagas disease (CD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center retrospective longitudinal study included 382 patients with chronic CD. The left atrioventricular coupling index (LACI) was defined as the ratio of left atrial (LA) over left ventricular (LV) end\u2010diastolic volumes. LA volumetric\/mechanical coupling index (LAVI\/A\u2019) was the ratio of maximum LA volume index over late diastolic mitral annulus velocity. The endpoint was a composite of all\u2010cause mortality or heart transplant. The associations between LACI or LAVI\/A\u2019 and the endpoint independent from clinical, electrocardiographic, and 2D echocardiographic parameters (Model I) or from Model I adjusting variables plus LV and LA strain parameters (Model II) were tested by multivariate Cox\u2010proportional\u2010hazards regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After a mean follow\u2010up of 6.6 \u00b1 2.7 years, 80 patients died and two underwent a heart transplant. LACI was associated with the endpoint in Models I (HR 1.03, 95% CI 1.01\u20131.05,\n                      <jats:italic>p =<\/jats:italic>\n                      0.01) and II (HR 1.03, 95% CI 1.01\u20131.05,\n                      <jats:italic>p =<\/jats:italic>\n                      0.0008). LAVI\/A\u2019 was also associated with the endpoint in Models I (HR 1.08, 95% CI 1.05\u20131.12,\n                      <jats:italic>P &lt;<\/jats:italic>\n                      0.0001) and II (HR 1.09, 95% CI 1.05\u20131.12,\n                      <jats:italic>P &lt;<\/jats:italic>\n                      0.0001). The area under the ROC curve was larger for LAVI\/A\u2019 than LACI (0.87\u00a0vs. 0.65,\n                      <jats:italic>P &lt;<\/jats:italic>\n                      0.0001). The optimal cutoff value for LAVI\/A\u2019 was 3.3 mL\u00a0\u00d7 s\/cm\n                      <jats:sup>\u22121<\/jats:sup>\n                      per m\n                      <jats:sup>2<\/jats:sup>\n                      (sensitivity 81.7%, specificity 83.7%). Patients with LAVI\/A\u2019 \u2265 3.3 at baseline had a 19\u2010fold higher risk for all\u2010cause mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>New echocardiographic LA coupling indexes are promising predictors of dismal clinical outcomes in CD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70560","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:16:45Z","timestamp":1785341805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Atrial Coupling Indexes as New Mortality Predictors in Chronic Chagas Disease"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2263-4261","authenticated-orcid":false,"given":"Roberto M.","family":"Saraiva","sequence":"first","affiliation":[{"name":"Clinical Research Laboratory in Chagas Disease Oswaldo Cruz Foundation, Fiocruz, Evandro Chagas National Institute of Infectious Diseases  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6369-3631","authenticated-orcid":false,"given":"Mauro Felippe F.","family":"Mediano","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory in Chagas Disease Oswaldo Cruz Foundation, Fiocruz, Evandro Chagas National Institute of Infectious Diseases  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-6555","authenticated-orcid":false,"given":"Henrique H.","family":"Veloso","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory in Chagas Disease Oswaldo Cruz Foundation, Fiocruz, Evandro Chagas National Institute of Infectious Diseases  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3125-6610","authenticated-orcid":false,"given":"Marcelo T.","family":"Holanda","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory in Chagas Disease Oswaldo Cruz Foundation, Fiocruz, Evandro Chagas National Institute of Infectious Diseases  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5033-4856","authenticated-orcid":false,"given":"Andr\u00e9a R.","family":"Costa","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory in Chagas Disease Oswaldo Cruz Foundation, Fiocruz, Evandro Chagas National Institute of Infectious Diseases  Rio de Janeiro Rio de Janeiro 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https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/chagas\u2010disease\u2010(american\u2010trypanosomiasis)."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.36660\/abc.20230269"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00751-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.055"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2024.12.082"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.120.011608"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20850"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jex154"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2022.100955"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.11.015"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.028810"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2020.06.003"},{"issue":"1","key":"e_1_2_12_14_1","first-page":"3","article-title":"2nd 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