{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:00:16Z","timestamp":1790586016364,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Left ventricular pressure\u2013strain loop (LV\u2010PSL) analysis provides non\u2010invasive myocardial\u2010work indices by integrating strain with contemporaneous brachial systolic blood pressure. Follow\u2010up myocardial\u2010work assessment requires blood pressure measured at the same assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe baseline myocardial mechanical abnormalities after percutaneous coronary intervention (PCI) for myocardial infarction and to explore associations between a 6\u2010week enhanced external counterpulsation (EECP) program and changes in global longitudinal strain (GLS) and rehabilitation outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single\u2010center matched observational study was conducted from October 2021 through January 2023. It included 66 patients after PCI for myocardial infarction who completed a 6\u2010week EECP program, 66 patients in a pre\u2010existing matched standard\u2010therapy comparator cohort, and 50 healthy reference participants. Baseline LV\u2010PSL\u2010derived myocardial\u2010work indices were descriptive. Six\u2010week between\u2010group changes in GLS, peak strain dispersion (PSD), N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP), 6\u2010min walk distance (6MWT), Seattle Angina Questionnaire (SAQ) summary score, and weekly angina frequency were analyzed using pair\u2010aware methods with Benjamini\u2013Hochberg false\u2010discovery\u2010rate (FDR) correction. A sensitivity analysis adjusted for baseline outcome value, baseline systolic blood pressure, heart rate, ST\u2010segment\u2010elevation myocardial infarction, ACEI\/ARB\/ARNI use, and calcium\u2010channel\u2010blocker use with pair\u2010clustered robust standard errors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Post\u2010PCI patients had less negative baseline GLS and descriptively lower constructive myocardial\u2010work values than healthy reference participants. In the matched exploratory comparison, the between\u2010group difference in GLS change was \u22121.3 percentage points (95% CI, \u22122.0 to \u22120.6;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001; FDR\n                      <jats:italic>q<\/jats:italic>\n                      &lt; 0.001). EECP exposure was also associated with larger improvements in 6MWT and SAQ score, a greater reduction in NT\u2010proBNP, and a greater reduction in weekly angina frequency; PSD change was not different after FDR correction. The adjusted sensitivity analysis gave a GLS difference of \u22121.3 percentage points (95% CI, \u22121.9 to \u22120.7;\n                      <jats:italic>P<\/jats:italic>\n                      &lt; 0.001; FDR\n                      <jats:italic>q<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this non\u2010randomized matched cohort, EECP exposure was associated with larger 6\u2010week improvements in GLS and selected rehabilitation outcomes. Baseline LV\u2010PSL\u2010derived myocardial work is presented only as descriptive context; no valid longitudinal myocardial\u2010work comparison was possible because follow\u2010up hemodynamic measurements were unavailable. The contribution of changes in loading conditions to GLS could not be assessed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70586","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:52:12Z","timestamp":1787730732000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Six\u2010Week Changes in Global Longitudinal Strain and Rehabilitation Outcomes After Enhanced External Counterpulsation Following PCI for Myocardial Infarction: An Analysis of a Pre\u2010Existing Matched Cohort"],"prefix":"10.1111","volume":"43","author":[{"given":"Juan","family":"Su","sequence":"first","affiliation":[{"name":"Department of Ultrasound Central Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Central Hospital Affiliated to Shandong First Medical University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuihuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Central Hospital Affiliated to Shandong First Medical University  Jinan Shandong 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