{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:00:16Z","timestamp":1790586016340,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac sarcomas and lymphomas are rare malignant tumors with distinct treatment strategies and prognoses. Accurate preoperative differentiation remains clinically challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included consecutive patients diagnosed with primary cardiac sarcoma or lymphoma between January 2010 and December 2024. All diagnoses were pathologically confirmed. Clinical profiles, echocardiographic features, imaging findings, and outcomes were systematically compared. Univariate and multivariate logistic regression analyses were performed to identify independent discriminatory factors, and receiver operating characteristic curves were used to evaluate diagnostic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four patients were enrolled (22 sarcomas, 22 lymphomas). Multivariate analysis identified younger age (OR: 1.08, 95% CI: 1.02\u20131.15;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.009) and isoechoic lesions (OR: 0.09, 95% CI: 0.01\u20130.91;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.041) as independent predictors of sarcoma, with the combined model yielding an AUC of 0.85 (95%CI: 0.71\u20130.94). Lymphomas more frequently exhibited mixed echogenicity (45.5%\u00a0vs. 13.6%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.016) and multi\u2010chamber involvement (50.0%\u00a0vs. 22.7%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.006). No significant survival difference was observed between groups (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      = 0.758).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Age and echogenicity pattern are key independent discriminators: hypoechoic masses in younger patients favor sarcoma, whereas mixed\u2011echoic masses in older patients suggest lymphoma. Histopathological confirmation remains essential, and clinicians should be aware of potential misdiagnosis by advanced imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70588","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T23:41:34Z","timestamp":1789256494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinguishing Cardiac Sarcomas From Lymphomas: Comparative Insights From Clinical and Echocardiographic Characteristics"],"prefix":"10.1111","volume":"43","author":[{"given":"Jingzhi","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Cardiac Ultrasound Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)\uff0cSouthern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwen","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Cardiac Ultrasound Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)\uff0cSouthern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiac Ultrasound Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences)\uff0cSouthern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21470\/1678-9741-2023-0405"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2020.09.102"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-024-01287-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016418"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15151951"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccao.2024.09.006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-022-03042-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.47"},{"key":"e_1_2_11_10_1","first-page":"599","article-title":"[Primary Cardiac Angiosarcoma: A Clinicopathological and Molecular Genetic Analysis of Thirteen Cases]","volume":"52","author":"Liu R.","year":"2023","journal-title":"Zhonghua Bing Li Xue Za Zhi Chinese Journal of Pathology"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.12.022"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15249"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2025.1685844"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2026.107017"},{"key":"e_1_2_11_15_1","article-title":"Primary Cardiac Myxofibrosarcoma of the Left Atrium With Heterologous Elements Mimicking a Cardiac Myxoma","volume":"26","author":"Medellin\u2010Vallejo R. 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