{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:21:19Z","timestamp":1787602879526,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Right ventricular (RV) dysfunction and increased pulmonary arterial (PA) pressure may occur in children with obstructive sleep apnea (OSA). Long\u2010term data on RV\u2010PA coupling in children with OSA with or without adenotonsillectomy are absent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included children aged 5 to 12 years diagnosed with tonsillar hypertrophy and moderate\u2010to\u2010severe OSA. All subjects underwent echocardiographic assessment and sleep study at least 5 years since initial recruitment. Right atrial, RV function and indexed pulmonary artery acceleration time (PAATi) were evaluated. RV\u2010PA coupling was assessed by tricuspid annular plane systolic excursion (TAPSE) \/ PAATi and RV global longitudinal strain (GLS) \/ PAATi.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We evaluated 160 subjects, including 38 with OSA who declined adenotonsillectomy (Group I), 80 with OSA post\u2010adenotonsillectomy (Group II), and 42 controls (Group III). Baseline demographics were similar across groups. At a mean follow\u2010up of 7.2 \u00b1 2.5 years, the latest OAHI did not differ significantly between the two OSA groups. Echocardiographic assessment revealed small intergroup differences in RA total strain, peak tricuspid annular systolic velocity, RVGLS and PAATi, whereas TAPSE, RV fractional area change and systolic strain rate were comparable across groups. Importantly, RV\u2010PA coupling indices did not differ significantly among the three groups. Furthermore, within the OSA cohort, neither follow\u2010up duration nor current OAHI severity correlated significantly with RV function or RV\u2010PA coupling indices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RV function and RV\u2010PA coupling are preserved in adolescents and young adults with a childhood diagnosis of OSA, irrespective of prior adenotonsillectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70590","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:28:23Z","timestamp":1786555703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Right Ventricular Function and Pulmonary Arterial Coupling in Paediatric Obstructive Sleep Apnea"],"prefix":"10.1111","volume":"43","author":[{"given":"Yumi Yuk\u2010ting","family":"Chan","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine School of Clinical Medicine LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Chung\u2010sum","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010ting","family":"Au","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis Lip\u2010yen","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie Moon\u2010wah","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Head and Neck Surgery The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka\u2010li","family":"Kwok","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Kwong Wah Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Pak\u2010lam","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hei\u2010to","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwok\u2010lap","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Martin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital  Hong Kong China"},{"name":"Department of Paediatrics The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate Ching\u2010ching","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The Chinese University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiu\u2010fai","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Adolescent Medicine School of Clinical Medicine LKS Faculty of Medicine The University of Hong Kong  Hong Kong China"},{"name":"Department of Paediatrics and Adolescent Medicine Hong Kong Children's Hospital  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2023.09.004"},{"issue":"7","key":"e_1_2_9_3_1","first-page":"375","article-title":"Obstructive Sleep Apnea and Cardiovascular Disease: Where Do We Stand?","volume":"27","author":"Peker Y.","year":"2023","journal-title":"Anatolian Journal of 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