{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:21:19Z","timestamp":1787602879885,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010term durability of degenerative mitral regurgitation (DMR) reduction after transcatheter edge\u2010to\u2010edge repair (TEER) remains limited, and reliable anatomical predictors are still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study prospectively enrolled patients with symptomatic DMR undergoing TEER across 27 centers in China. All pre\u2010procedural clinical and echocardiographic parameters were collected and analyzed. The primary outcome was MR \u2264 1+ at 3\u2010year follow\u2010up. Logistic regression and receiver operating characteristic (ROC) analyses were performed to identify predictors and optimal cutoff values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 78 patients with available 3\u2010year echocardiographic assessments were included in the imaging\u2010based analysis (mean age, 74.4 \u00b1 5.1 years; 67.9% with NYHA class III\/IV symptoms; mean STS score for mitral valve replacement, 6.8 \u00b1 2.7%). At 3\u2010year follow\u2010up, 49 patients (62.8%) maintained MR \u22641+. TEER was associated with significant reverse cardiac remodeling, including reductions in left ventricular end\u2010diastolic volume (125.4 \u00b1 40.6 to 99.8 \u00b1 19.7\u00a0mL) and pulmonary artery systolic pressure (43.0 \u00b1 11.6 to 34.3 \u00b1 11.4\u00a0mmHg) (both\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), while LVEF remained stable. Mitral valve (MV) prolapse\/flail width independently predicted MR durability (OR: 0.789; 95% CI: 0.655\u20130.951;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.013). ROC analysis identified a cutoff value of 16\u00a0mm (AUC: 0.714;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002), with patients having prolapse\/flail width \u226516\u00a0mm demonstrating lower rates of MR \u22641+ at 3 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre\u2010procedural prolapse\/flail width is an independent predictor of 3\u2010year MR durability after TEER in patients with DMR. Larger prolapse\/flail width is associated with reduced mid\u2010term MR stability, suggesting its potential value for risk stratification and procedural planning.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This study has been registered at ClinicalTrials.gov with a number of NCT04734756.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70596","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T15:45:10Z","timestamp":1786463110000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Prolapse Width for Mid\u2010Term Degenerative Mitral Regurgitation Stability After Transcatheter Edge\u2010to\u2010Edge Repair"],"prefix":"10.1111","volume":"43","author":[{"given":"Xinping","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Cardiology, School of Medicine, The Second Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"State Key Laboratory of Transvascular Implantation Devices  Hangzhou Zhejiang China"},{"name":"Transvascular Implant Instrument Research Institute The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boren","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, The Second Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"State Key Laboratory of Transvascular Implantation Devices  Hangzhou Zhejiang China"},{"name":"Transvascular Implant Instrument Research Institute The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, The Second Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"State Key Laboratory of Transvascular Implantation Devices  Hangzhou Zhejiang China"},{"name":"Transvascular Implant Instrument Research Institute The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, The Second Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"State Key Laboratory of Transvascular Implantation Devices  Hangzhou Zhejiang China"},{"name":"Transvascular Implant Instrument Research Institute The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixiang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, The Second Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"State Key Laboratory of Transvascular Implantation Devices  Hangzhou Zhejiang China"},{"name":"Transvascular Implant Instrument Research Institute The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, The Second Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"State Key Laboratory of Transvascular Implantation Devices  Hangzhou Zhejiang China"},{"name":"Transvascular Implant Instrument Research Institute The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianbao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, School of Medicine, The Second Affiliated Hospital Zhejiang University  Hangzhou Zhejiang China"},{"name":"State Key Laboratory of Transvascular Implantation Devices  Hangzhou Zhejiang China"},{"name":"Transvascular Implant Instrument Research Institute The Second Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.077"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab910"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.11.034"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2025.08.039"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.09.015"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2021.12.007"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392\u2010025\u201002644\u20101"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacasi.2025.05.013"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.70215"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2022.07.004"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.30698"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","unstructured":"P. M.Doldi L.Stolz D.Kalbacher et\u00a0al. \u201cRight Ventricular Dysfunction Predicts Outcome After Transcatheter Mitral Valve Repair for Primary Mitral Valve Regurgitation \u201d24 no.11(2022):2162\u20132171 https:\/\/doi.org\/10.1002\/ejhf.2661.","DOI":"10.1002\/ejhf.2661"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.08.016"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacasi.2025.10.006"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.70384"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4244\/eij\u2010d\u201023\u201000361"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jet105"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.01.003"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.10.002"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.02.031"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.125.045616"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.112.118083"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.70596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:28:34Z","timestamp":1787599714000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.70596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/echo.70596"],"URL":"https:\/\/doi.org\/10.1111\/echo.70596","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2026-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70596"}}