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RV longitudinal strain, derived from 2D speckle\u2010tracking echocardiography, has emerged as a quantitative, angle\u2010independent marker of myocardial deformation, enabling earlier detection of dysfunction and providing incremental diagnostic and prognostic value beyond traditional indices in selected settings. RV free\u2010wall longitudinal strain is most commonly used in clinical practice, with established reference values and growing applicability across a broad spectrum of cardiovascular and pulmonary diseases, including pulmonary hypertension, heart failure, ischemic heart disease, cardiomyopathies, and valvular heart disease. However, despite growing evidence supporting its clinical utility, its integration into routine decision\u2010making remains limited. Important constraints persist, particularly inter\u2010vendor variability and relatively high test\u2013retest variability, which affect reproducibility and limit standardization. Emerging techniques, including three\u2010dimensional strain, and artificial intelligence\u2013based analysis, once sufficiently validated and standardized, hold potential to improve measurement accuracy and reproducibility.<\/jats:p>","DOI":"10.1111\/echo.70615","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T22:42:01Z","timestamp":1789598521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Applications of Right Ventricular Strain by Two\u2010Dimensional Speckle\u2010Tracking Echocardiography"],"prefix":"10.1111","volume":"43","author":[{"given":"Anca","family":"Balinisteanu","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery University of Medicine and Pharmacy \u201cCarol Davila\u201d  Bucharest Romania"},{"name":"Department of Cardiovascular Sciences KU Leuven  Leuven 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