{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:49:19Z","timestamp":1792511359875,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Echocardiographic assessment of right ventricular (RV) function remains challenging because conventional functional and deformation indices are strongly influenced by loading conditions. Right ventricular myocardial work (RVMW), derived by integrating myocardial deformation with ventricular pressure, has emerged as a potential framework for contextualizing RV mechanics according to afterload. However, its methodology, validation, clinical applications, and readiness for routine use have not been comprehensively mapped.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A scoping review was conducted in accordance with Joanna Briggs Institute methodology and reported according to PRISMA\u2010ScR. MEDLINE via PubMed was systematically searched from inception through August 14, 2026. The search was supplemented by targeted terminology\u2010based searches, backward and forward citation tracking, reference\u2010list screening, and searches using individual RVMW indices. Original human studies quantitatively evaluating echocardiography\u2010derived RVMW were eligible. Data were charted regarding study characteristics, RVMW methodology, pressure source, work indices, validation strategy, clinical application, prognostic value, reproducibility, and methodological limitations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty\u2010nine studies met the eligibility criteria. The evidence encompassed several related but methodologically distinct RVMW constructs: 27 studies primarily used conventional non\u2010invasive subpulmonary RV pressure\u2013strain\u2010loop analysis, three regional myocardial\u2010work approaches, two systemic\u2010RV myocardial work, two invasive\u2010pressure\u2010integrated approaches, two single\u2010ventricle\/Fontan approaches, and three emerging three\u2010dimensional or volume\u2010integrated pressure\u2013strain\u2013volume\/pressure\u2013volume methods. These constructs differ in pressure source, ventricular geometry, and mathematical derivation and are not numerically interchangeable. The literature evolved from early physiological and proof\u2010of\u2010concept investigations toward invasive validation, reference\u2010value assessment, disease\u2010specific phenotyping, interventional studies, and preliminary prognostic applications. Pulmonary hypertension represented the most extensively investigated clinical domain, while applications expanded to heart failure, congenital and systemic\u2010RV physiology, mechanical circulatory support, structural interventions, pediatric populations, and physiological adaptation. Substantial heterogeneity remained in strain definition, RV segmentation, pressure estimation, pressure\u2010curve construction, and analytical methodology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Echocardiography\u2010derived RVMW is a promising integrative framework that contextualizes RV deformation according to prevailing pressure load and may provide complementary information beyond conventional RV functional indices. Current evidence is strongest in pulmonary hypertension, while applications across other cardiovascular and systemic conditions are expanding. Nevertheless, methodological heterogeneity, limited multicenter validation, absence of universally accepted reference values and disease\u2010specific thresholds, and uncertain incremental clinical utility currently preclude routine implementation. Standardized RV\u2010specific methodology and prospective studies demonstrating management\u2010relevant incremental value are required before RVMW can become a routinely actionable echocardiographic measure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70620","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:50:19Z","timestamp":1789465819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Right Ventricular Myocardial Work by Echocardiography: A Scoping Review of Methodology, Validation, and Clinical Applications"],"prefix":"10.1111","volume":"43","author":[{"given":"Ehsan","family":"Shahverdi","sequence":"first","affiliation":[{"name":"Department of Cardiology Rhythmology, Angiology and Intensive Care Medicine Klinikum Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rhythmology, Angiology and Intensive Care Medicine Klinikum Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rhythmology, Angiology and Intensive Care Medicine Klinikum Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.12.076"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2025.01.006"},{"key":"e_1_2_12_4_1","first-page":"153","volume-title":"Right Ventricular Work: A Step Forward for Non\u2010Invasive Assessment of Right Ventricular Function","author":"Smiseth O. 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