{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:56:33Z","timestamp":1790668593395,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To explore the value of real\u2010time three\u2010dimensional echocardiography (RT\u20103DE) in evaluating right ventricular (RV) structure and function in patients with pulmonary hypertension (PH) across different echocardiographic pulmonary artery systolic pressure (PASP) strata.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 150 patients with PH and 84 healthy controls were included. Patients with PH were stratified into mild, moderate and severe echocardiographic PASP strata. Conventional two\u2010dimensional (2D) echocardiographic parameters and RT\u20103DE\u2013derived RV parameters were compared among groups. Correlations between echocardiographic parameters and pulmonary pressure burden were analyzed. Cross\u2010validated receiver operating characteristic analyses were performed to evaluate the diagnostic performance of 2D parameters, RT\u20103DE parameters and combined 2D plus RT\u20103DE models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PH etiologies included Group 1 pulmonary arterial hypertension (31.3%), Group 2 PH due to left heart disease (51.3%), Group 3 PH due to lung disease and\/or hypoxia (11.3%), Group 4 PH associated with pulmonary artery obstruction (1.4%), and Group 5 PH with unclear and\/or multifactorial mechanisms (4.7%). RV\u2010TD, RV\/LV ratio, RAEA, and RV\u2010FW increased across echocardiographic PASP strata, whereas S\u2032, TAPSE, RVFAC, and RVEF decreased. RT\u20103DE\u2010derived RV volume and functional parameters differed significantly among groups; within the PH cohort, RVEDV, RVESV, RVSV, and RV cardiac output increased across PASP strata, while RVEF progressively decreased. The combined 2D plus RT\u20103DE model showed high cross\u2010validated discrimination for moderate\u2010to\u2010severe PH and severe PH, with AUCs of 0.956 and 0.998, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combined 2D echocardiography and RT\u20103DE provide complementary noninvasive information for evaluating RV remodeling and systolic dysfunction in patients with PH across different echocardiographic PASP strata.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70621","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:17:59Z","timestamp":1790666279000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Value of Real\u2010Time Three\u2010Dimensional Echocardiography for Evaluating Right Ventricular Structure and Function in Patients With Pulmonary Hypertension Across Different Echocardiographic Pulmonary Artery Systolic Pressure Strata"],"prefix":"10.1111","volume":"43","author":[{"given":"Junlan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Ultrasound Tangshan Central Hospital  Tangshan City Hebei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound North China University of Science and Technology Affiliated Hospital  Tangshan City Hebei Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.4402"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112137\u201020201008\u201002778"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac237"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01913\u20102018"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02334\u20102021"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2022.02.007"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10153229"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2025.01.006"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2024.0313"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1365798"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1672\u20105131.2020.05.035"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.12122\/j.issn.1674\u20104500.2025.06.12"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn131148\u201020200227\u201000115"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2010.05.010"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.4250\/jcu.2011.19.3.115"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.12125\/j.chj.202402019"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2134585"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001415"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HHF.0000000000000088"},{"issue":"8","key":"e_1_2_12_22_1","first-page":"1490","article-title":"The 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