{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:00:15Z","timestamp":1790586015352,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Left ventricular ejection fraction (LVEF) recovery after transcatheter aortic valve implantation (TAVI) varies among patients with severe aortic stenosis and reduced LVEF. We characterized serial changes in LVEF and examined their associations with ischemic heart disease (IHD) and baseline left ventricular end\u2010diastolic diameter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Among 685 patients who underwent TAVI between 2014 and 2024, 121 with native\u2010valve severe aortic stenosis and baseline LVEF &lt; 50% were analyzed. Echocardiography was performed before TAVI, early after TAVI (median, 3 days), and at 1, 6, and 12 months. Serial LVEF recovery was evaluated using linear mixed\u2010effects models incorporating all available post\u2010TAVI measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LVEF improved significantly through 1 year, with a model\u2010estimated increase of 12.3 percentage points (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001); left ventricular end\u2010diastolic diameter, end\u2010systolic diameter, and mass index also decreased. In multivariable mixed\u2010effects models, IHD, baseline LVEF, baseline left ventricular end\u2010diastolic diameter, and baseline mean aortic valve pressure gradient were associated with serial LVEF recovery. Adjusted recovery was greatest in patients without IHD and with smaller left ventricular end\u2010diastolic diameter and most limited in those with IHD and larger left ventricular end\u2010diastolic diameter.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>TAVI was associated with serial LVEF improvement and left ventricular reverse remodeling. IHD and larger baseline left ventricular end\u2010diastolic diameter were associated with limited LVEF recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70626","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:05:54Z","timestamp":1789466754000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serial Changes in Left Ventricular Ejection Fraction After Transcatheter Aortic Valve Implantation: Associations With Ischemic Heart Disease and Left Ventricular End\u2010Diastolic Diameter"],"prefix":"10.1111","volume":"43","author":[{"given":"Koji","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Cardiology Shizuoka City Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetaka","family":"Kageyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shizuoka City Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Cardiology Shizuoka City Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riho","family":"Sano","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shizuoka City Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shizuoka City Shizuoka Hospital  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Shizuoka City Shizuoka Hospital  Shizuoka 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