{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:00:16Z","timestamp":1790586016397,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Global longitudinal strain (GLS) is the recommended marker for cancer therapy\u2013related cardiac dysfunction (CTRCD) but may miss the earliest myocardial changes. We examined whether early decline in left atrial strain (LAS) precedes GLS change in patients who subsequently develop CTRCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a single\u2010center retrospective cohort of 62 women with breast cancer, speckle\u2010tracking echocardiography measured LAS and GLS at baseline (T0), after the fourth anthracycline cycle (T1), and 3\u20136 months after treatment (T2). CTRCD (2022 ESC criteria) was classified by onset (T1 or T2). Analyses were exploratory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CTRCD occurred in 26 patients (41.9%): 8 T1\u2010onset, 18 T2\u2010onset. In T2\u2010onset patients, the early (T0\u2192T1) relative decline in LA reservoir strain (LASr) already exceeded that of no\u2010CTRCD patients (\u221219.5 \u00b1 13.9%\u00a0vs \u22126.4 \u00b1 11.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001), whereas early GLS change did not differ (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.43). Early LASr change had the highest area under the curve (AUC) for subsequent CTRCD (0.78; 95% CI 0.65\u20130.90) versus GLS (0.59; DeLong\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.10). An exploratory 6.35% LASr decline threshold gave 100% sensitivity (95% CI 82\u2013100%), 56% specificity (95% CI 40\u201371%), and 100% negative predictive value; bootstrap\u2010corrected AUC was 0.77. LASr and GLS were only weakly\u2010to\u2010moderately correlated (r = \u22120.29 baseline; r = \u22120.41 early change).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this small retrospective cohort, early LASr decline was associated with, and tended to precede, GLS change in women who subsequently developed anthracycline\u2010associated CTRCD. These hypothesis\u2010generating findings support LASr as a potential early, high\u2010sensitivity adjunctive marker requiring prospective validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70629","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:00:06Z","timestamp":1789599606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Atrial Strain as an Early Marker of Anthracycline\u2010Related Cardiac Dysfunction (LAS\u2010MACD)"],"prefix":"10.1111","volume":"43","author":[{"given":"Chonthicha","family":"Tanking","sequence":"first","affiliation":[{"name":"Department of Cardiology Chulabhorn Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanthasit","family":"Samansit","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chulabhorn Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanwit","family":"Wuttichaipradit","sequence":"additional","affiliation":[{"name":"Department of Cardiology Chulabhorn Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13399"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.1096"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_100015"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013777"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac244"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.020"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.01.059"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2021.09.009"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12820"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12947\u2010020\u201000210\u20105"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.11.066"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt\u201020\u2010461"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12227127"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeaa339"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15805"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey042"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.70629","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:43:42Z","timestamp":1790585022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.70629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/echo.70629"],"URL":"https:\/\/doi.org\/10.1111\/echo.70629","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70629"}}