{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:00:19Z","timestamp":1790586019948,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ischemic mitral regurgitation (IMR) reflects left ventricular (LV) remodeling, but its within\u2010patient trajectory during sequential medical therapy and coronary revascularization remains incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare within\u2010patient changes in LV remodeling and IMR severity during the medical\u2010therapy and subsequent post\u2010revascularization intervals and examine the association between LV reverse remodeling and IMR regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center retrospective complete\u2010case serial\u2010imaging cohort, 125 adults with significant IMR underwent quantitative echocardiography at baseline, after medical therapy, and 2\u20133 months after PCI or CABG. The primary endpoint was \u22651\u2010grade IMR improvement from baseline to final follow\u2010up. Patient\u2010level changes during the medical\u2010therapy and subsequent post\u2010revascularization intervals were compared using Wilcoxon signed\u2010rank tests with Holm adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median LVEDV reduction was 3\u00a0mL (IQR \u22124 to 19) during the medical\u2010therapy interval versus 22\u00a0mL (IQR 5\u201351) during the post\u2010revascularization interval. Corresponding improvements were 1 versus 8 percentage points for LVEF, 0.02 versus 0.16 cm\n                      <jats:sup>2<\/jats:sup>\n                      for EROA, and 2 versus 21\u00a0mL\/beat for regurgitant volume (Holm\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001 for all comparisons). Overall, 93 patients (74.4%) achieved \u22651\u2010grade IMR improvement. LV reverse remodeling occurred in 80 (64.0%) and was strongly associated with IMR improvement. Excluding 25 patients with &gt;50% LVEDV reduction yielded consistent findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Serial echocardiography demonstrated substantially greater ventricular and IMR improvement during the post\u2010revascularization interval than during the preceding medical\u2010therapy interval. These temporal associations do not establish an independent causal effect of revascularization but support serial echocardiographic assessment of ventricular remodeling and residual IMR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70636","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:08:45Z","timestamp":1790150925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serial Echocardiographic Changes in Left Ventricular Remodeling and Ischemic Mitral Regurgitation During Medical Therapy and After Coronary Revascularization: A Contemporary Cohort Study"],"prefix":"10.1111","volume":"43","author":[{"given":"Jamilah","family":"AlRahimi","sequence":"first","affiliation":[{"name":"Department of Cardiology, King Abdulaziz Medical City Ministry of National Guard Health Affairs  Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"},{"name":"College of Medicine King Saud bin Abdulaziz University For Health Sciences  Jeddah Saudi Arabia"},{"name":"Department of Cardiovascular Technology Echocardiography College of Applied Medical Sciences, King Saud Bin Abdulaziz University For Health Sciences  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan","family":"Asiri","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"},{"name":"Department of Cardiovascular Technology Echocardiography College of Applied Medical Sciences, King Saud Bin Abdulaziz University For Health Sciences  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Albogami","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"},{"name":"Department of Cardiovascular Technology Echocardiography College of Applied Medical Sciences, King Saud Bin Abdulaziz University For Health Sciences  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laila","family":"Assiri","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"},{"name":"Department of Cardiovascular Technology Echocardiography College of Applied Medical Sciences, King Saud Bin Abdulaziz University For Health Sciences  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Cardiology, King Abdulaziz Medical City Ministry of National Guard Health Affairs  Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center  Jeddah Saudi Arabia"},{"name":"Department of Cardiovascular Technology Echocardiography College of Applied Medical Sciences, King Saud Bin Abdulaziz University For Health Sciences  Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28350"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(12)61728\u20100"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.28770"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/aca.ACA_58_17"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.486720"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016006"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.06.039"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.10.64"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1089253218792921"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000087656.10829.DF"},{"issue":"3","key":"e_1_2_11_13_1","article-title":"Current Prognosis of Ischemic Mitral Regurgitation","volume":"78","author":"Hickey M. 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