{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:53:43Z","timestamp":1791132823304,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess right ventricular (RV) systolic trajectories across right ventricular pacing (RVP) burdens and their relationship with left ventricular (LV) remodeling in patients with preserved baseline LV ejection fraction (LVEF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective study included 200 patients undergoing dual\u2010chamber pacemaker implantation with an apical RV lead. Clinical, electrocardiographic, device, and echocardiographic assessments were performed at baseline, three months, and 12 months. Patients were grouped by RVP burden: 0%\u20133% (\n                      <jats:italic>n<\/jats:italic>\n                      = 43), 70%\u201379% (\n                      <jats:italic>n<\/jats:italic>\n                      = 51), or \u226580% (\n                      <jats:italic>n<\/jats:italic>\n                      = 106). RV global longitudinal strain (RVGLS), RV fractional area change (RVFAC), and tricuspid annular plane systolic excursion (TAPSE) were evaluated using adjusted linear mixed\u2010effects models. Continuous RVP associations and concurrent RV\u2013LV changes were examined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 200 patients (median age, 79 years), adjusted mixed\u2010effects models demonstrated significantly different longitudinal trajectories across RVP groups for RVGLS (Holm\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0096) and TAPSE (Holm\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      = 0.050), but not for RVFAC (Holm\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      = 0.252). RVGLS and TAPSE deteriorated with high RVP while remaining comparatively stable with minimal pacing. Within the 70%\u2013100% range, each 10% higher RVP burden was associated with an additional TAPSE reduction of 0.305 at 3\u2010months (95%CI, 0.084, 0.527;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007) and 0.401\u00a0mm at 12\u2010months (95%CI, 0.179, 0.622\u00a0mm;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The overall continuous time\u2010by\u2010RVP interaction was significant for TAPSE (Holm\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0035), but not for RVGLS or RVFAC. Worsening LVGLS was associated with deterioration in all RV indices at both assessments (FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.0017), while increasing LV end\u2010systolic volume was associated with all RV indices at 12\u2010months (all FDR\u2010adjusted\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Substantial RVP was associated with statistically detectable changes in RV indices. Within the high\u2010pacing range, greater RVP burden was associated with a greater longitudinal decline in TAPSE. Concurrent RV\u2010LV changes were also present, although their clinical significance requires further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70647","type":"journal-article","created":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T16:41:42Z","timestamp":1791132102000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Right Ventricular Pacing Burden\u2013Dependent Biventricular Remodeling in Patients With Preserved Left Ventricular Ejection Fraction: A Prospective Longitudinal Study"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1691-644X","authenticated-orcid":false,"given":"Onoufrios","family":"Malikides","sequence":"first","affiliation":[{"name":"Department of Cardiology University General Hospital of Heraklion  Heraklion Greece"},{"name":"Medical School University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Marketou","sequence":"additional","affiliation":[{"name":"Department of Cardiology University General Hospital of Heraklion  Heraklion Greece"},{"name":"Medical School University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4320-0010","authenticated-orcid":false,"given":"Andria","family":"Papazachariou","sequence":"additional","affiliation":[{"name":"Medical School University of Crete  Heraklion Greece"},{"name":"Department of Internal Medicine University General Hospital of Heraklion  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vironas","family":"Malikides","sequence":"additional","affiliation":[{"name":"Medical School University of Crete  Heraklion Greece"},{"name":"Department of Internal Medicine University General Hospital of Heraklion  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Chlouverakis","sequence":"additional","affiliation":[{"name":"Medical School University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftherios","family":"Kallergis","sequence":"additional","affiliation":[{"name":"Department of Cardiology University General Hospital of Heraklion  Heraklion Greece"},{"name":"Medical School University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Patrianakos","sequence":"additional","affiliation":[{"name":"Department of Cardiology University General Hospital of Heraklion  Heraklion Greece"},{"name":"Medical School University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Simantirakis","sequence":"additional","affiliation":[{"name":"Department of Cardiology University General Hospital of Heraklion  Heraklion Greece"},{"name":"Medical School University of Crete  Heraklion Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.08.015"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.006"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12872"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes15060671"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2025.17"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14249"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2025.102007"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14701"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.06.004"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq031"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010021\u201002429\u20100"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14017431.2020.1820565"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1365798"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2023.02.007"},{"key":"e_1_2_13_17_1","first-page":"142","article-title":"Diastolic and Systolic Right Ventricular Dysfunction Precedes Left Ventricular Dysfunction in Patients Paced From Right Ventricular Apex","volume":"6","author":"Dwivedi S. 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