{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:35:08Z","timestamp":1793032508468,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Echocardiography"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To compare left atrial (LA) structure and phasic function among healthy controls and patients with nonobstructive or obstructive hypertrophic cardiomyopathy (HCM), and assess their associations with left ventricular outflow tract obstruction (LVOTO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We studied 90 patients with HCM and 50 healthy controls. Patients were classified by the highest resting or Valsalva\u2010provoked LVOT gradient (LVOTG) as nonobstructive (&lt;30\u00a0mmHg;\n                      <jats:italic>n<\/jats:italic>\n                      = 50) or obstructive (\u226530\u00a0mmHg;\n                      <jats:italic>n<\/jats:italic>\n                      = 40). Threedimensional echocardiography measured LA volumes, and two\u2010dimensional speckle tracking measured phasic strain. Multivariable linear regression examined prespecified echocardiographic outcomes by LVOTO status. Sensitivity analyses modeled LVOTG continuously and used a 50\u2010mmHg threshold.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both HCM groups had greater LA enlargement and dysfunction than controls, with the largest abnormalities in obstructive HCM. In the primary adjusted model, LVOTO was associated with higher LAVImin (\n                      <jats:italic>B<\/jats:italic>\n                      = 10.03\u00a0mL\/m\n                      <jats:sup>2<\/jats:sup>\n                      ; 95% CI, 6.71 to 13.36;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and lower LASr (\n                      <jats:italic>B<\/jats:italic>\n                      = \u22122.72%; 95% CI, \u22124.17 to \u22121.28;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The associations remained when LVOTG was analyzed per 10\u00a0mmHg and with a threshold of \u226550\u00a0mmHg. E\/e\u2032 and TRV were not significantly associated with LVOTG in these sensitivity analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this cross\u2010sectional HCM cohort, greater obstruction severity was associated with higher LAVImin and lower LASr. Prospective studies are needed to determine whether these measures are associated with clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/echo.70653","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:24:22Z","timestamp":1792682662000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Left Ventricular Outflow Tract Obstruction with Left Atrial Remodeling and Dysfunction in Hypertrophic Cardiomyopathy: A Three\u2010Dimensional Echocardiography and Left Atrial Strain Study"],"prefix":"10.1111","volume":"43","author":[{"given":"Weili","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui'e","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulai","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine The Third Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-025-00643-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.12.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001250"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-23-1206"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13533"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004052"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1168514"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.13886"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.115.004229"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jey042"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15691"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-021-02520-9"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.14740\/cr1690"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.03.012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/cdt.2019.02.01"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245934"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2024.132135"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2024.08.005"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeae136"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-021-02232-0"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.121.013556"}],"container-title":["Echocardiography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70653","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/echo.70653","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/echo.70653","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:45:10Z","timestamp":1793029510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/echo.70653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":21,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/echo.70653"],"URL":"https:\/\/doi.org\/10.1111\/echo.70653","archive":["Portico"],"relation":{},"ISSN":["0742-2822","1540-8175"],"issn-type":[{"value":"0742-2822","type":"print"},{"value":"1540-8175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70653"}}