{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:35:57Z","timestamp":1782531357532,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Although high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP) is currently used as a risk marker of cardiovascular disease, it has been suggested that genetic, clinical, biochemical or environmental factors could modify hs\u2010CRP levels. The aim of this study was to investigate sources of interindividual hs\u2010CRP variability in the Spanish population.<\/jats:p><jats:p><jats:bold>Materials and methods\u2002<\/jats:bold> A representative sample of the Spanish population within the di@bet.es study was used. Study variables included a clinical and demographic structured survey, a lifestyle survey, a physical examination, plasmatic hs\u2010CRP and other biochemical parameters.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Median and interquartile range of plasma hs\u2010CRP values were 1\u00b773\u2003\u00b1\u20032\u00b775\u2003mg\/dL. Thirty per cent of the study population had hs\u2010CRP levels above 3\u2003mg\/dL and 38% from 1 to 3\u2003mg\/dL. Body mass index was the strongest factor associated with moderate and high hs\u2010CRP levels. Age, sex, waist\u2010to\u2010hip ratio, weight increase, plasma lipid levels, glucose metabolism (HOMA\u2010IR and abnormal glucose regulation categories), pharmacological treatment (lipid\u2010lowering agents, psychotropic drugs and levothyroxine), smoking, physical activity, different dietary patterns, quality of life and educational level were all significantly associated with hs\u2010CRP levels. Interactions were observed between variables. These interactions modulated the effect of previously described factors on hs\u2010CRP.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Thirty per cent of the Spanish population have hs\u2010CRP levels considered to represent a cardiovascular risk. Different clinical, anthropometric, biochemical and environmental variables modulate hs\u2010CRP levels. In addition, multiple interactions between variables complicate the interpretation of hs\u2010CRP values.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12002","type":"journal-article","created":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T16:40:34Z","timestamp":1346517634000},"page":"1-10","source":"Crossref","is-referenced-by-count":12,"title":["Factors determining high\u2010sensitivity C\u2010reactive protein values in the Spanish population. 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