{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:46:18Z","timestamp":1789940778581,"version":"4.0.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,28]],"date-time":"2012-10-28T00:00:00Z","timestamp":1351382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Although mortality risk associated with obstructive sleep apnoea (OSA) tends to disappear from the age of 50, it has been suggested that OSA treatment by continuous positive airway pressure (CPAP) improves survival even in older subjects. Life expectancy of subjects with several diseases is worse if OSA coexists. The objectives of this study were to evaluate the relevance of comorbidities in the relationship between OSA and mortality, and in the effect of CPAP on survival, in subjects \u2265\u200350\u2003years old.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Data from 810 patients studied by polysomnography for suspected OSA between 1991 and 2000 were retrospectively evaluated. In 2009, state of survival and use of CPAP were enquired. Three hundred and thirteen subjects were &lt;\u200350 and 497 were \u2265\u200350\u2003years at diagnosis.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> Age and comorbidities, but not apnoea\/hypopnoea index (AHI) or lowest nocturnal arterial oxygen saturation (Nadir SaO<jats:sub>2<\/jats:sub>), predicted mortality in the whole sample. Nadir SaO<jats:sub>2<\/jats:sub> was related to mortality among the younger subjects without comorbidities (<jats:italic>P<\/jats:italic>\u2003=\u20030\u00b701), but not among the older subjects. In the older patients with an AHI\u2003&gt;\u200330 CPAP treatment was associated with a better survival only if comorbidities coexisted.<\/jats:p><jats:p><jats:bold>Conclusions\u2002<\/jats:bold> Unlike in younger subjects, in subjects \u2265\u200350\u2003years old, comorbidities do not mask an effect of OSA on mortality. Among OSA subjects \u2265\u200350\u2003years old, comorbidities could separate those who may expect an improvement in survival with CPAP treatment from those who may not. Possibly, after the age of 50, OSA <jats:italic>per se<\/jats:italic> does not affect survival, but worsens prognosis of subjects with coexisting diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12011","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T02:13:45Z","timestamp":1348539225000},"page":"27-33","source":"Crossref","is-referenced-by-count":35,"title":["Comorbidities and survival in obstructive sleep apnoea beyond the age of 50"],"prefix":"10.1111","volume":"43","author":[{"given":"Oreste","family":"Marrone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Lo Bue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Salvaggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Dardanoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Insalaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,28]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.1.9"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)71141-7"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00051504"},{"key":"e_1_2_8_5_2","first-page":"1071","article-title":"Sleep disordered breathing and mortality: eighteen\u2010year follow\u2010up of the Wisconsin Sleep Cohort","volume":"31","author":"Young T","year":"2008","journal-title":"Sleep"},{"key":"e_1_2_8_6_2","first-page":"1079","article-title":"Sleep apnea as an independent risk factor for all\u2010cause mortality: the Busselton Health Study","volume":"31","author":"Marshall NS","year":"2008","journal-title":"Sleep"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000132"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/18.3.149"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00306502"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.96.5.1054"},{"key":"e_1_2_8_11_2","article-title":"Sleep disturbances and risk of frailty and mortality in older men","author":"Ensrud KE","journal-title":"Sleep Med"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.78.5.544"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2009.00754.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/sleep\/18.6.433","article-title":"Four\u2010year follow\u2010up of mortality and sleep\u2010related respiratory disturbance in non\u2010demented seniors","volume":"18","author":"Mant A","year":"1995","journal-title":"Sleep"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs019"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.4.277"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.94.6.1200"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b18.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.2.624"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.6.2076"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-2-201201170-00006"},{"key":"e_1_2_8_22_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5664\/jcsm.1648","article-title":"Assessment of multiple health risks in a single obstructive sleep apnea population","volume":"8","author":"Hudgel DW","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"e_1_2_8_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812450256"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.162.1.9905035"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.1464"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.05.057"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2007.70"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.160952"},{"key":"e_1_2_8_29_2","first-page":"1333","article-title":"Sleep\u2010disordered breathing and COPD: the overlap syndrome","volume":"55","author":"Owens RL","year":"2010","journal-title":"Respir Care"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq756"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201201-0130OC"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.02.008"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200808-1341OC"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00192008"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1869OC"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2007.00578.x"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.2008.S16"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2008.04.014"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9706079"},{"key":"e_1_2_8_40_2","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1093\/sleep\/15.suppl_6.S39","article-title":"Sleep apnea syndrome in the elderly","volume":"15","author":"Fleury B","year":"1992","journal-title":"Sleep"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.6.1489"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1136"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.99.14612719"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.4.875"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-1055-x"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.1422"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.5.623"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-0842"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12011","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T23:51:08Z","timestamp":1697586668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,28]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/eci.12011"],"URL":"https:\/\/doi.org\/10.1111\/eci.12011","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,28]]}}}