{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:52:36Z","timestamp":1780087956135,"version":"3.54.0"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,7]],"date-time":"2012-11-07T00:00:00Z","timestamp":1352246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:label\/><jats:p>Eur J Clin Invest 2012<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Aims\u2002<\/jats:bold> The lectin\u2010like oxidized low\u2010density lipoprotein receptor\u20101 (LOX\u20101), encoded by the OLR1 gene, has been implicated in the pathogenesis of atherosclerosis. We therefore evaluated the genotyping of OLR1 gene in a sample of 55 patients with Metabolic Syndrome, a clinical condition characterized by a high cardiovascular risk.<\/jats:p><jats:p><jats:bold>Methods and Patients\u2002<\/jats:bold> The genotyping of the LOX\u20101 was performed by polymerase chain reaction (PCR) analysis of the IVS4\u201014 A&gt;G OLR1 polymorphism embedded within the OLR1 Linkage Disequilibrium block. Patients were assessed for routine serum parameters, microalbuminuria, insulin resistance (HOMA) and oxidative stress (thiobarbituric acid reactive substances, TBARs and thioredoxin).<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> The allele or genotype distribution of the OLR1 IVS4\u201014 A&gt;G was not statistically different between MS and controls subjects. A positive association was found between IVS4\u201014 GG genotype, microalbuminuria and fasting glycaemia as well as a higher frequency of type 2 diabetes, elevated microalbuminuria, fasting serum glucose and HOMA index in the same subjects. Thioredoxin values were higher in patients with MS but did not differ in relation to OLR1 IVS4\u201014 A&gt;G genotype. The TBARs\/Cholesterol ratio was higher in MS both in IVS4\u201014 GG and in IVS4\u201014 AG.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> IVS4\u201014 GG genotype seems to be related to glucose metabolism disturbance, elevated insulin level and lipid peroxidation in patients with MS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12013","type":"journal-article","created":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T09:13:09Z","timestamp":1348650789000},"page":"41-48","source":"Crossref","is-referenced-by-count":14,"title":["Oxidized LDL Receptor 1 gene polymorphism in patients with Metabolic Syndrome"],"prefix":"10.1111","volume":"43","author":[{"given":"Vincenzo O.","family":"Palmieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigida","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Grattagliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Casieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Cardinale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Palasciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Di Serio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,7]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2007.06.011"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.683"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.2.385"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/386073a0"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.09.006"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00236-X"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.03.036"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.20.4.1107"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00382.2002"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7176"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.83.3.322"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5674"},{"key":"e_1_2_8_14_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/bj3390177","article-title":"Structure and chromosomal assignment of the human lectin\u2010like oxidized low\u2010density lipoprotein receptor 1 (LOX\u20101) gene","volume":"39","author":"Aoyama T","year":"1999","journal-title":"Biochem J"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.12.933"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000074207.85796.36"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000174563.62625.8e"},{"key":"e_1_2_8_18_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/sj.ejhg.5201513","article-title":"On the association of the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction or coronary artery disease","volume":"14","author":"Trabetti E","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2005.06.002"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2009.0101"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.2174\/157489007780832506"},{"key":"e_1_2_8_22_2","volume-title":"Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","author":"National Institutes of Health","year":"2001"},{"key":"e_1_2_8_23_2","unstructured":"International Task Force for Prevention of Coronary Heart Disease(http:\/\/www.chd\u2010taskforce.com\/coronary_risk_assessment.html). 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