{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:46:26Z","timestamp":1763685986909},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec><jats:label \/><jats:p>Eur J Clin Invest 2012<\/jats:p><\/jats:sec><jats:sec><jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Different factors are involved in the development of diabetic nephropathy (DN). Oxidative stress and inflammation play an important role in the pathogenesis of DN. Ferulsinaic Acid (FA) was isolated in 2007. In 2011, we found that FA prolonged the lifespan of <jats:italic>C.\u00a0elegans<\/jats:italic> due to its antioxidative effect, and we hypothesized that FA restores the kidney function of diabetic rats via its antioxidant activity.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Male Wistar rats were injected with STZ and divided into 5 groups of 10 each: control, diabetic untreated, diabetic treated with 500, 750 and 1000\u2003ng\/kg FA. FA treatment was continued for 21\u2003weeks after induction of diabetes.<\/jats:p><jats:p><jats:bold>Results\u2002<\/jats:bold> In the diabetic rats treated with FA, fasting blood sugar, HbA1C kidney\/body weight ratio, creatinine, BUN, sodium and albuminurea were significantly decreased compared with untreated diabetic rats. Diabetic rats showed decreased activities of superoxide dismutase, glutathione peroxidase and catalase, increased concentrations of malondialdehyde and IL\u20106 in the kidney homogenate. In addition levels of 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine in the urine and in the renal cortex DNA were increased. Moreover, severe destruction in glomerular and tubulointerstitial lesions such as glomerular sclerosis, atrophy, interstitial expansion and interstitial cellular infiltration was seen in the kidney of the diabetic untreated rats. Furthermore, the diabetic kidney was found to be positive for NF\u2010\u03baB p65 antigen in the immunohistochemistry examinations. Treatment with FA restored all the altered parameters in a dose\u2010dependent manner. Furthermore, all the ultra\u2010morphologic abnormalities and NF\u2010\u03baB activation in the kidney of diabetic rats were markedly ameliorated by FA treatment.<\/jats:p><jats:p><jats:bold>Conclusion\u2002<\/jats:bold> FA confers a considerable protection against kidney injuries of the diabetic rats by increasing activities of antioxidant enzymes, attenuating the formation of AGEs, attenuating the NF\u2010\u03baB activation, ameliorating the inflammatory markers and inhibiting the accumulation of oxidized DNA in the kidney, suggesting a potential drug for the prevention and therapy of DN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12015","type":"journal-article","created":{"date-parts":[[2012,10,8]],"date-time":"2012-10-08T07:26:13Z","timestamp":1349681173000},"page":"56-63","source":"Crossref","is-referenced-by-count":6,"title":["Ferulsinaic acid attenuation of diabetic nephropathy"],"prefix":"10.1111","volume":"43","author":[{"given":"Ahmed A. R.","family":"Sayed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,11,28]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2096"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.3181\/0705-MR-134"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00027.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/323171"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1056-8727(01)00143-X"},{"key":"e_1_2_7_8_2","first-page":"475","article-title":"Protective role of intraperitoneally administered vitamin E and selenium on the oxidative defense mechanisms in rats with diabetes induced by streptozotocin","volume":"47","author":"Naziroglu M","year":"2001","journal-title":"Biol Trace Elem Res"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0091-5"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1211\/002235702450"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1021\/np0201671"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.3987\/REV-02-561"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2006.12.011"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01222.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/580104"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0076-4"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(72)80218-3"},{"key":"e_1_2_7_18_2","first-page":"808","article-title":"Thymoquinone and proanthocyanidin attenuation of diabetic nephropathy in rats","volume":"16","author":"Sayed AA","year":"2012","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_2_7_19_2","first-page":"355","article-title":"Assay for lipid peroxides in animal tissue by thiobarbituric acid","volume":"95","author":"Okhawa H","year":"1979","journal-title":"Anal Biochem"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0139-6"},{"key":"e_1_2_7_21_2","first-page":"582","article-title":"Levels of glutathione, glutathione reductase and glutathione S\u2010transferase activities in rat lung and liver","volume":"67","author":"Moron MS","year":"1979","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/10715760290006510"},{"key":"e_1_2_7_23_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2337\/diab.42.2.345","article-title":"Immunochemical detection of advanced glycation end products in lens crystallins from streptozocin\u2010induced diabetic rat","volume":"42","author":"Nakayama H","year":"1993","journal-title":"Diabetes"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-012-0107-x"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0567"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.12.2792"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.4.405"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.10.2603"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/nep078"},{"key":"e_1_2_7_30_2","article-title":"Modulation of the Cellular Expression of Circulating Advanced Glycation End\u2010Product Receptors in Type 2 Diabetic Nephropathy","volume":"2010","author":"Sourris KC","year":"2010","journal-title":"Evid Based Complement Alternat Med"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(97)00035-5"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2011.01361.x"},{"key":"e_1_2_7_33_2","first-page":"281","article-title":"Kataya and AlaaEldin A. Hamza. Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats","volume":"5","author":"Hazem AH","year":"2008","journal-title":"eCAM"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1082039"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1454"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.12.3532"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0118-y"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T23:51:19Z","timestamp":1697586679000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,28]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1111\/eci.12015"],"URL":"https:\/\/doi.org\/10.1111\/eci.12015","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,28]]}}}