{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:58:41Z","timestamp":1715601521016},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T00:00:00Z","timestamp":1356652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although stable angina pectoris often carries a favourable prognosis, it remains important to identify patients with an increased risk of cardiovascular (CV) complications. Many new markers of disease activity and prognosis have been described. We evaluated whether common and easily accessible markers in everyday care provide sufficient prognostic information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ngina <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ectoris <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>rognosis <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudy in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tockholm treated 809 patients (248 women) with stable angina pectoris with metoprolol or verapamil double blind during a median follow\u2010up of 3\u00b74\u00a0years, with a registry\u2010based extended follow\u2010up after 9\u00b71\u00a0years. Clinical and mechanistic variables, including lipids and glucose, renal function, ambulatory and exercise\u2010induced ischaemia, heart rate variability, cardiac and vascular ultrasonography, and psychosocial variables were included in an integrated analysis. Main outcome measures were nonfatal myocardial infarction (MI) and CV death combined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 139 patients (18 women) suffered a main outcome. Independent predictive variables were (odds ratio [95% confidence intervals]), age (1\u00b704 per year [1\u00b700;1\u00b708], <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7041), female sex (0\u00b733 [0\u00b716;0\u00b769], <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001), fasting blood glucose (1.29 per mM [1.14; 1.46], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001), serum creatinine (1\u00b702 per \u03bcM [1\u00b700;1\u00b703], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and leucocyte counts (1\u00b721 per 10<jats:sup>6<\/jats:sup>\u00a0cells\/L [1\u00b706;1\u00b740], <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008). Smoking habits, lipids and hypertension or a previous MI provided limited additional information. Impaired fasting glucose was as predictive as manifest diabetes and interacted adversely with serum creatinine. Sexual problems were predictive among men.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Easily accessible clinical and demographic variables provide a good risk prediction in stable angina pectoris. Impaired glucose tolerance and an elevated serum creatinine are particularly important.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12025","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T12:17:44Z","timestamp":1352722664000},"page":"141-151","source":"Crossref","is-referenced-by-count":7,"title":["Risk prediction in stable angina pectoris"],"prefix":"10.1111","volume":"43","author":[{"given":"Thomas","family":"Kahan","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Clinical Sciences Danderyd Hospital, Karolinska Institutet Stockholm Sweden"},{"name":"Department of Cardiology Danderyd University Hospital Corp Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Forslund","sequence":"additional","affiliation":[{"name":"Medical Products Agency Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Held","sequence":"additional","affiliation":[{"name":"Uppsala Clinical Research Centre Department of Medical Sciences Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Bj\u00f6rkander","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Clinical Sciences Danderyd Hospital, Karolinska Institutet Stockholm Sweden"},{"name":"Department of Cardiology Danderyd University Hospital Corp Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Billing","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven V.","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Clinical Sciences Danderyd Hospital, Karolinska Institutet Stockholm Sweden"},{"name":"Department of Cardiology Danderyd University Hospital Corp Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"N\u00e4sman","sequence":"additional","affiliation":[{"name":"Centre for Safety Research The Royal Institute of Technology KTH Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Rehnqvist","sequence":"additional","affiliation":[{"name":"The Swedish Council on Technology Assessment in Health Care (SBU) Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Hjemdahl","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Clinical Pharmacology Unit Karolinska University Hospital (Solna) Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,12,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.057703"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a014886"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2005.01643.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01728.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1451"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.10.2380"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(97)00147-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(99)00240-3"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1936"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00526-3"},{"key":"e_1_2_8_13_1","first-page":"398","article-title":"The prognostic value of left ventricular size and function in patients with stable angina. 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