{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:41:33Z","timestamp":1791654093509,"version":"4.3.4"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,7]],"date-time":"2013-01-07T00:00:00Z","timestamp":1357516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The metabolic syndrome (MetS) affects iron homeostasis in a many\u2010faceted fashion. On the one side, hyperferritinaemia with normal or mildly elevated transferrin saturation is observed in approximately one\u2010third of patients with non\u2010alcoholic fatty liver disease (<jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>) or the MetS. This constellation has been named the \u2018dysmetabolic iron overload syndrome (<jats:styled-content style=\"fixed-case\">DIOS<\/jats:styled-content>)\u2019. Current evidence suggests that elevated body iron stores exert a detrimental effect on the clinical course of obesity\u2010related conditions and that iron removal improves insulin sensitivity and delays the onset of T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>. On the other side, iron deficiency is a frequent finding in more progressed stages of obesity. The mechanisms underlying the <jats:styled-content style=\"fixed-case\">DIOS<\/jats:styled-content> and obesity\u2010related iron deficiency appear strikingly similar as elevated hepcidin concentrations, low expression of duodenal ferroportin (<jats:styled-content style=\"fixed-case\">FPN<\/jats:styled-content>) and impaired iron absorption are found in both conditions. This review summarizes the current knowledge about the dysregulation of iron homeostasis in the MetS and particularly in its hepatic manifestation <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/eci.12032","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T19:18:25Z","timestamp":1353957505000},"page":"215-224","source":"Crossref","is-referenced-by-count":147,"title":["Iron homeostasis in the Metabolic Syndrome"],"prefix":"10.1111","volume":"43","author":[{"given":"Christian","family":"Datz","sequence":"first","affiliation":[{"name":"Department of Internal Medicine General Hospital Oberndorf Oberndorf Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas K.","family":"Felder","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Paracelsus Medical University, Salzburg 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