{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:17:30Z","timestamp":1772749050978,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,5]],"date-time":"2013-02-05T00:00:00Z","timestamp":1360022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,4]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Pentraxin 3 (PTX<\/jats:styled-content>3) is a cytokine\u2010inducible molecule expressed in different tissues, the levels of which increase in a response to a variety of inflammatory conditions. Recently, it has been linked to the serum glucose levels and some comorbidities in type 2 diabetes.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>Here, we aimed to investigate the role of PTX<\/jats:styled-content>3 in gestational diabetes mellitus (GDM<\/jats:styled-content>), which is considered a forerunner of type 2 diabetes. Fasting PTX<\/jats:styled-content>3 serum levels were measured in 90 women [45 GDM<\/jats:styled-content>, 45 normal glucose tolerance (NGT<\/jats:styled-content>)] during pregnancy. In addition, PTX<\/jats:styled-content>3 was measured during a 2\u00a0h, 75\u00a0g oral glucose tolerance test (OGTT<\/jats:styled-content>) in 20 women (10 GDM<\/jats:styled-content>, 10 NGT<\/jats:styled-content>) at 24\u201328\u00a0weeks of gestation and in 16 of them after delivery (10GDM<\/jats:styled-content>, 6 NGT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>A continuous increase in PTX<\/jats:styled-content>3 levels was observed during the OGTT<\/jats:styled-content> and reached in the GDM<\/jats:styled-content> group a significant difference after 120\u00a0min compared with baseline (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b705). Additionally, a rise in the PTX<\/jats:styled-content>3 concentration was significantly higher in the GDM<\/jats:styled-content>\u2010 compared with the NGT<\/jats:styled-content> group, 120\u00a0min after glucose challenge (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b701). During pregnancy, serum glucose and C\u2010peptide were positively correlated with the PTX<\/jats:styled-content>3 levels in the whole study group, whereas a negative association was found with the insulin sensitivity parameters QUICKI<\/jats:styled-content> and OGIS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Dependence of PTX<\/jats:styled-content>3 on serum glucose levels was more pronounced in women with GDM<\/jats:styled-content> than in the NGT<\/jats:styled-content> group. This notion together with its inverse relation to the parameters of insulin sensitivity, suggests a potential involvement of PTX<\/jats:styled-content>3 in GDM<\/jats:styled-content> pathology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12051","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T02:15:57Z","timestamp":1357784157000},"page":"341-349","source":"Crossref","is-referenced-by-count":21,"title":["Relationship of pentraxin 3 with insulin sensitivity in gestational diabetes"],"prefix":"10.1111","volume":"43","author":[{"given":"Jelena","family":"Todoric","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ammon","family":"Handisurya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Nephrology and Dialysis Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Knapp","sequence":"additional","affiliation":[{"name":"Department for Biosimulation and Bioinformatics Center for Medical Statistics Informatics and Intelligent Systems Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Tura","sequence":"additional","affiliation":[{"name":"Metabolic Unit Institute of Biomedical Engineering National Research Council Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pacini","sequence":"additional","affiliation":[{"name":"Metabolic Unit Institute of Biomedical Engineering National Research Council Padova Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Kautzky\u2010Willer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Division of Endocrinology and Metabolism Medical University of Vienna Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115756"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/367338a0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200324390"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"22190","DOI":"10.1016\/S0021-9258(18)41653-5","article-title":"d'Aniello EM, Golay J, Peri G, Bottazzi B, Bairoch A, et al. 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