{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T15:14:50Z","timestamp":1725981290593},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T00:00:00Z","timestamp":1363305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010sensitivity <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein (hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>) is a sensitive inflammatory marker suggested for cardiovascular risk stratification. This study aimed to assess the potential genetic determinants for serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels in a cohort with well\u2010controlled nondiabetic hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Ethnic <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese nondiabetic hypertensive patients were enrolled in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aiwan. They received comprehensive evaluation including history taking, physical check\u2010up, blood pressure (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>) measurement, 24\u2010h ambulatory <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> monitoring and blood sampling. Serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels were determined. <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> genotyping was performed in two stages. In the first stage, 4 single\u2010nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) of <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> including rs1572970, rs2794520, rs3093077 and rs2808630 were investigated in the 400 participants. In the second stage, only <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s significant in the first stage were selected for complete genotyping in the whole population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total 915 consecutive patients (40\u00b79\u00a0\u00b1\u00a07\u00b73\u00a0years, 68\u00b73% male) completed the study. Two of the 4 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s including rs1572970 and rs3093077 were correlated to hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels in the whole population. Stepwise multiple linear regression indicated that age (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001), body mass index (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001), waist\u2013hip ratio (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7032), smoking habits (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001), night\u2010time systolic <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7040), total cholesterol (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7005) and <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> rs3093077 polymorphism (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001) were independently associated with serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels. Overall, genetic correlates explained 2\u00b74%, <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> explained 11\u00b79% and all other clinical correlates explained 4\u00b78% of interindividual variability in serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010reactive protein genotype contributed limitedly to serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels in subjects with well\u2010controlled hypertension, suggesting the impacts of clinical rather than genetic determinants to serum hs\u2010<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels for cardiovascular risk stratification in this intermediate\u2010risk Taiwanese cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12067","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T16:21:36Z","timestamp":1361204496000},"page":"449-456","source":"Crossref","is-referenced-by-count":13,"title":["Genetic variation in <scp>C<\/scp>\u2010reactive protein in ethnic <scp>C<\/scp>hinese population in <scp>T<\/scp>aiwan"],"prefix":"10.1111","volume":"43","author":[{"given":"Chin\u2010Chou","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Medical Research and Education Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University Taipei Taiwan"},{"name":"Institute of Pharmacology National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Min","family":"Chung","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Biomedical Sciences Academia Sinica Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Bang","family":"Leu","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Cardiovascular Research Center National Yang\u2010Ming University Taipei Taiwan"},{"name":"Healthcare and Management Center Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Clinical Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsung\u2010Hsien","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cardiology 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