{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T05:25:01Z","timestamp":1708925101631},"reference-count":153,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lupus is a prototype autoimmune disease of unknown aetiology. The disease is complex; manifest diverse clinical symptoms and disease mechanisms. This complexity has provided many leads to explore: from disease mechanisms to approaches for therapy. <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010lymphocytes play a central role in the pathogenesis of the disease. However, the cause of aberrant <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010lymphocyte responses in patients and, indeed, its causal relationship with the disease remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This article provides a synopsis of current knowledge of immunological abnormalities in lupus with an emphasis on abnormalities in the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010lymphocyte compartment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There is evidence for abnormalities in most compartments of the immune system in animal models and patients with lupus including an ever expanding list of abnormalities within the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010lymphocyte compartment. In addition, recent genome\u2010wide linkage analyses in large cohorts of patients have identified new sets of genetic association factors some with potential links with defective <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010lymphocyte responses although their full pathophysiological effects remain to be determined. The accumulating knowledge may help in the identification and application of new targeted therapies for treating lupus disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cellular, molecular and genetic studies have provided significant insights into potential causes of immunological defects associated with lupus. Most of this insight relate to defects in <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010lymphocyte tolerance, signalling and responses. For <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>\u2010lymphocytes, there is evidence for altered regulation of inter and intracellular signalling pathways at multiple levels. Some of these abnormalities will be discussed within the context of potential implications for disease pathogenesis and targeted therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12111","type":"journal-article","created":{"date-parts":[[2013,5,2]],"date-time":"2013-05-02T21:07:46Z","timestamp":1367528866000},"page":"866-880","source":"Crossref","is-referenced-by-count":7,"title":["Aberrant <scp>B<\/scp>\u2010lymphocyte responses in lupus: inherent or induced and potential therapeutic targets"],"prefix":"10.1111","volume":"43","author":[{"given":"Taher E.","family":"Taher","sequence":"first","affiliation":[{"name":"Bone &amp; Joint Research Unit William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hawzheen A.","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Bone &amp; Joint Research Unit William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad","family":"Rahim","sequence":"additional","affiliation":[{"name":"Bone &amp; Joint Research Unit William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Flores\u2010Borja","sequence":"additional","affiliation":[{"name":"Division of Cancer Studies School of Medicine King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Renaudineau","sequence":"additional","affiliation":[{"name":"Immunology Laboratory University of Brest Medical School Brest France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Isenberg","sequence":"additional","affiliation":[{"name":"Centre for Rheumatology UCL Division of Medicine University College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizgar A.","family":"Mageed","sequence":"additional","affiliation":[{"name":"Bone &amp; Joint Research Unit William Harvey Research Institute Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,5,23]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"819","volume-title":"Oxford Textbook of Rheumatology","author":"Ehrenstein M","year":"2004"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20999"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ken247"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302016"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104549"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2091"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3223"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199807)41:7<1241::AID-ART15>3.0.CO;2-H"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.35"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199807)41:7<1161::AID-ART4>3.0.CO;2-K"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.81"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2459"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.9.5338"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/clim.2002.5192"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh663"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.182.3.1689"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.117135"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(98)01395-4"},{"key":"e_1_2_11_20_1","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.4049\/jimmunol.155.4.2269","article-title":"TCR\/CD3 complex\u2010mediated signal transduction pathway in T cells and T cell lines from patients with systemic lupus erythematosus","volume":"155","author":"Vassilopoulos D","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem154"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.11.6627"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081886"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.3.853"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00201-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042251"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21571"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/14.4.411"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.4.2074"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1074900"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1782"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-006-0037-0"},{"key":"e_1_2_11_33_1","first-page":"1621","article-title":"Induction of systemic lupus erythematosus by interferon\u2010gamma in a patient with rheumatoid arthritis","volume":"18","author":"Graninger WB","year":"1991","journal-title":"J Rheumatol"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1916"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102973"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1488"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009234107"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20487"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2004.04.008"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1262"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132541"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.6.2987"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2008.07.048"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80554-3"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5288.798"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90075-6"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/11.10.1685"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.2310\/6650.2001.34042"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21416"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27505"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707865"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.06.033"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.1.589"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803941"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22309"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.11.001"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/35053086"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(06)00188-6"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02363.x"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040912"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.2001.1845"},{"key":"e_1_2_11_62_1","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.4049\/jimmunol.162.9.5278","article-title":"CD45 regulates tyrosine phosphorylation of CD22 and its association with the protein tyrosine phosphatase SHP\u20101","volume":"162","author":"Greer SF","year":"1999","journal-title":"J Immunol"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.1.329"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/381325a0"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5436.2122"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119073"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1994.tb06289.x"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20081268"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700373104"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011330200"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-001-2123-x"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5455.1049"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5455.1040"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20020805"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.24.8580-8591.2002"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-3041"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101602"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1291"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2012.04.001"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.6.4.3837"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.08.015"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073560"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900432"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0809585"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2009.03.010"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2007.10.003"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2036"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1284"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1957"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04627.x"},{"key":"e_1_2_11_91_1","first-page":"497","article-title":"Systemic lupus erythematosus\u2010like autoimmune abnormalities induced by bacterial infection","volume":"21","author":"Tomita H","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052438"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.06.009"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1443.012"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22571"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006101162"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.07.013"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22197"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24686"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.019"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036035"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830170916"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1435"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200604014"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.12.2223"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.6.3264"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636248"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.5.2695"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2133"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00936.x"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1256"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M403507200"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker101"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152208785748368"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24341"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2009.218"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3910"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2012.11.006"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker337"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3179"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1942"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-013-0015-8"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10763"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23673"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1061964"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3524"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23047"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar2506"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61354-2"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312465781"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2009.01458.x"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.10.29"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0254-6"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10681"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7520604"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21417"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050524"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34624"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.10.017"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117373"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2011.03964.x"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201310"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27221"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200008)43:8<1790::AID-ANR15>3.0.CO;2-2"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20576"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200011)43:11<2383::AID-ANR2>3.0.CO;2-D"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900615106"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.34632"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.144485"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.166.3.798"},{"key":"e_1_2_11_151_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10167"},{"key":"e_1_2_11_152_1","unstructured":"ClinicalTrials.gov.\u201cSafety Study of AMG 811 in Subjects with Systemic Lupus Erythematosus With and Without Glomerulonephritis \u201d (NCT00818948) August 2011. Available at:http:\/\/www.clinicaltrials.gov."},{"key":"e_1_2_11_153_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/578641"},{"key":"e_1_2_11_154_1","first-page":"229","article-title":"New insight in the mechanism of action of rituximab: the interferon signature towards personalized medicine","volume":"11","author":"Verweij CL","year":"2011","journal-title":"Discov Med"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T11:41:47Z","timestamp":1696246907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,23]]},"references-count":153,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["10.1111\/eci.12111"],"URL":"https:\/\/doi.org\/10.1111\/eci.12111","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,23]]}}}