{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:10:06Z","timestamp":1770739806590,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate comprehensively the effects of 12 prophylaxis interventions for secondary prophylaxis of variceal bleeding using multiple\u2010treatments meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pub<jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ed, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochrane <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ibrary were searched prior to <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2011. Randomized controlled trials (<jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s) comparing the interventions for secondary prophylaxis of variceal bleeding. The primary study outcomes were variceal rebleeding, mortality due to rebleeding and mortality due to all causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We systematically reviewed 51 <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>s. Transjugular intrahepatic portosystemic shunt (<jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content>), \u03b2\u2010blockers combined with endoscopic injection sclerotherapy (<jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content>) and endoscopic banding ligation (<jats:styled-content style=\"fixed-case\">EBL<\/jats:styled-content>) combined with <jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content> were superior to \u03b2\u2010blockers [odds ratios (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 0\u00b713, 0\u00b723 and 0\u00b713, respectively] and <jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content> (0\u00b719, 0\u00b734 and 0\u00b718, respectively) in reducing the rate of rebleeding. To reduce the mortality rate due to rebleeding, <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content> was more efficacious than \u03b2\u2010blockers (0\u00b711), <jats:styled-content style=\"fixed-case\">EBL<\/jats:styled-content> (0\u00b713), <jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content> (0\u00b719), \u03b2\u2010blockers combined with isosorbide\u20105\u2010mononitrate (5\u2010<jats:styled-content style=\"fixed-case\">ISMN<\/jats:styled-content>) (0\u00b716) and \u03b2\u2010blockers combined with <jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content> (0\u00b714). In addition, \u03b2\u2010blockers combined with 5\u2010<jats:styled-content style=\"fixed-case\">ISMN<\/jats:styled-content> were significantly more efficacious than \u03b2\u2010blockers (0\u00b756) and <jats:styled-content style=\"fixed-case\">EBL<\/jats:styled-content> (0\u00b764) to reduce the mortality rate due to all causes. <jats:styled-content style=\"fixed-case\">EBL<\/jats:styled-content> combined with argon plasma coagulation showed the best profile of reduction in rebleeding rate and mortality rate due to all causes. To reduce the mortality rate due to rebleeding, <jats:styled-content style=\"fixed-case\">TIPS<\/jats:styled-content> had the highest probability. <jats:styled-content style=\"fixed-case\">EBL<\/jats:styled-content> combined with <jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content> was the best choice according to the cumulative probabilities of being among the three most efficacious interventions for the three outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endoscopic banding ligation combined with <jats:styled-content style=\"fixed-case\">EIS<\/jats:styled-content> might be the first choice in the secondary prophylaxis of varices bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12115","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T10:20:27Z","timestamp":1368008427000},"page":"844-854","source":"Crossref","is-referenced-by-count":18,"title":["Secondary prophylaxis of variceal bleeding for cirrhotic patients: a multiple\u2010treatments meta\u2010analysis"],"prefix":"10.1111","volume":"43","author":[{"given":"Ke\u2010Qing","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center the First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"Institute of Hepatology Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center the First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"School of the First Clinical Medical Sciences Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Zhen","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center the First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian\u2010Feng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center the First Affiliated Hospital of Wenzhou Medical University Wenzhou China"},{"name":"School of the First Clinical Medical Sciences Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center the First Affiliated Hospital of Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Infection and Liver Diseases Liver Research Center the First Affiliated Hospital of Wenzhou Medical 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