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Cholestasis is the pivotal hallmark of the so\u2010called primary cholestatic liver diseases but may also emerge in other forms of chronic liver injury. The aim now was to summarise the current state of knowledge on intrahepatic cholestasis related to chronic liver diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this overview on intrahepatic cholestasis in chronic liver disorders other than the \u2018classic\u2019 cholestatic liver diseases, selected references were retrieved by literature search in<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>and textbooks were reviewed. All articles were selected that discussed pathophysiological and clinical aspects of intrahepatic cholestasis in the context of alcoholic liver disease, nonalcoholic fatty liver disease, chronic hepatitis B and C virus infections as well as drug\u2010induced and granulomatous liver diseases. Titles referring to primary biliary cirrhosis and sclerosing cholangitis were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusions<\/jats:title><jats:p>Dependent on the aetiology, intrahepatic cholestasis is present at variable frequencies and in different disease stages in chronic liver diseases. Cholestasis secondary to chronic liver injury may denote a severe disease course and development of end\u2010stage liver disease or specific disease variants. These findings indicate that \u2018secondary intrahepatic cholestasis\u2019 (<jats:styled-content style=\"fixed-case\">SIC<\/jats:styled-content>) can occur in the natural course of chronic liver diseases other than the primary cholestatic diseases, in particular in the setting of advanced disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12128","type":"journal-article","created":{"date-parts":[[2013,6,20]],"date-time":"2013-06-20T13:40:38Z","timestamp":1371735638000},"page":"1069-1083","source":"Crossref","is-referenced-by-count":64,"title":["Intrahepatic cholestasis in common chronic liver diseases"],"prefix":"10.1111","volume":"43","author":[{"given":"Christoph","family":"J\u00fcngst","sequence":"first","affiliation":[{"name":"Department of Medicine II Saarland University Medical Center Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Berg","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology and Rheumatology Division of Hepatology Leipzig University Hospital Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Liver Center of Beijing Ditan Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Green","sequence":"additional","affiliation":[{"name":"Division of Hepatology Department of Medicine Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jidong","family":"Jia","sequence":"additional","affiliation":[{"name":"Liver Research Center Beijing Friendship Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Mason","sequence":"additional","affiliation":[{"name":"Center of Excellence in Gastrointestinal Inflammation and Immunity Research University of Alberta Edmonton AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[{"name":"Department of Medicine II Saarland University Medical Center Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.05.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2010.07.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.04.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.09.002"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365527809179824"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(19)35811-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1089-3261(05)70086-6"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810223391707"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22014"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80401-5"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01536804"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1253227"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.134"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.22646"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25614"},{"key":"e_1_2_10_18_1","first-page":"210","article-title":"Prognostic factors in alcoholic liver disease. 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