{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T04:46:26Z","timestamp":1781757986741,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T00:00:00Z","timestamp":1384128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sleep is essential for the maintenance of an intact immune function. Patients with sleep apnoea experience frequent sleep interruption due to apnoea\u2010related arousals, possibly adversely impacting their immunity and affecting their outcomes when confronting sepsis. This case\u2013control study aimed to compare the outcomes of sepsis patients with and without sleep apnoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 2000 to 2009, 168 sleep apnoea patients who were first admitted for sepsis were identified from the Taiwan National Health Insurance Research Database. Also, 672 sepsis patients without sleep apnoea, who were matched by age, gender and Charlson's comorbidity index scores, served as controls. Hospital outcomes of the two groups were compared. Binary logistic regression was employed for multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mortality rates of sepsis patients with and without sleep apnoea were 60\u00b71% and 47\u00b79%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005). After multivariate adjustment, sleep apnoea (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1\u00b7805, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b7227\u20132\u00b7656, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003), presence of shock (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 3\u00b7600, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 2\u00b7144\u20136\u00b7046, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and number of organs with dysfunction (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 1\u00b7591, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1\u00b7087\u20132\u00b7329, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7017) were found to be independently associated with mortality. Sleep apnoea patients who needed continuous positive airway pressure treatment had an even higher risk of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sepsis patients with sleep apnoea may have poorer hospital outcomes than those without sleep apnoea.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12187","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:09:04Z","timestamp":1381543744000},"page":"38-45","source":"Crossref","is-referenced-by-count":11,"title":["Sleep apnoea patients have higher mortality when confronting sepsis"],"prefix":"10.1111","volume":"44","author":[{"given":"Chien\u2010Yu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine Taipei Hospital Ministry of Health and Welfare Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Tai","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine Heping Fuyou Branch Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010An","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Heping Fuyou Branch Taipei City Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Jen","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Oncology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Public Health Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010Chuan","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Institute of Emergency and Critical Care Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diahn\u2010Warng","family":"Perng","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh\u2010Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzeng\u2010Ji","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Hospital and Health Care Administration School of Medicine National Yang\u2010Ming University Taipei Taiwan"},{"name":"Department of Family Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Chin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun\u2010Ta","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Chest Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Faculty of Medicine School of Medicine Taipei Taiwan"},{"name":"Institute of Clinical Medicine School of Medicine National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.130.3.780"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.189420"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-1044-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06616.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05300.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.4.R905"},{"key":"e_1_2_10_8_1","first-page":"R1148","article-title":"Sustained sleep deprivation impairs host defense","volume":"265","author":"Everson CA","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2008.505"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.12.1469"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PSY.0000091382.61178.F1"},{"key":"e_1_2_10_12_1","first-page":"1063","article-title":"Sleep and antibody response to hepatitis B vaccination","volume":"35","author":"Prather AA","year":"2012","journal-title":"Sleep"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000050454.01978.3B"},{"key":"e_1_2_10_14_1","unstructured":"National Health Research Institutes.Introduction to the National Health Insurance Research Database (updated 2007). Available at:http:\/\/w3.nhri.org.tw\/nhird\/\/date_01.html. Accessed April 1 2013."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.07.003"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1086\/597509"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-2205"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200107000-00002"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1097\/ALN.0b013e31823422e8","article-title":"Advances in the management of sepsis and the understanding of key immunologic defects","volume":"115","author":"Skrupky LP","year":"2011","journal-title":"Anesthesiology"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200208-785OC"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.4037\/ccn2012689"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-1591(03)00031-X"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.08.005"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2741\/s176"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08071161"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.4.447"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3181e6dabf"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425910385962"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2010.02332.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2012.62"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-008-1243-0"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000297885.60037.6E"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048307"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/ags081"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.1.9706079"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.08.017"}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12187","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T01:19:15Z","timestamp":1696295955000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,11]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/eci.12187"],"URL":"https:\/\/doi.org\/10.1111\/eci.12187","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,11]]}}}