{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:23:58Z","timestamp":1785536638969,"version":"3.56.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T00:00:00Z","timestamp":1384387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Previous research indicated that coeliac disease (CD<\/jats:styled-content>) is associated with type 1 diabetes mellitus (T1DM<\/jats:styled-content>). However, the gut\u2010brain axis peptide hormones secretion has not been evaluated so far in patients with CD<\/jats:styled-content> prior to treatment initiation or under treatment, irrespective of patients having concomitant T1DM<\/jats:styled-content> or not. The aim of the study was therefore to evaluate these gut hormones at the preprandial levels of patients with CD<\/jats:styled-content> before and under treatment.<\/jats:p><\/jats:sec>Methods<\/jats:title>Of forty\u2010seven CD<\/jats:styled-content> children, 12 untreated (UCD<\/jats:styled-content>), 22 treated with gluten\u2010free diet (TCD<\/jats:styled-content>) and 13 treated CD<\/jats:styled-content> with coexisting T1DM<\/jats:styled-content> (DCD<\/jats:styled-content>), and 18 healthy controls (HC<\/jats:styled-content>) were enrolled. Preprandial glucagon\u2010like\u2010peptide\u20101 (GLP<\/jats:styled-content>\u20101), glucose\u2010dependent\u2010insulinotropic\u2010polypeptide (GIP<\/jats:styled-content>), active amylin, acylated ghrelin (AG<\/jats:styled-content>), leptin, pancreatic polypeptide (PP<\/jats:styled-content>) and peptide\u2010tyrosine\u2010tyrosine (PYY<\/jats:styled-content>) were determined with hormone\u2010map\u2010array technology.<\/jats:p><\/jats:sec>Results<\/jats:title>We found in patients with CD<\/jats:styled-content> compared with HC<\/jats:styled-content> that the concentration of (i) GLP<\/jats:styled-content>\u20101 was reduced remarkably in all patients with CD<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00\u00b7008), (ii) GIP<\/jats:styled-content> was lower in patients with UCD<\/jats:styled-content> (P<\/jats:italic>\u00a0=\u00a00\u00b7008), (iii) amylin was remarkably reduced (P<\/jats:italic>\u00a0<\u00a00\u00b701) in all patients with CD<\/jats:styled-content>, (iv) AG<\/jats:styled-content> was significantly decreased in patients with DCD<\/jats:styled-content> (P<\/jats:italic>\u00a0<\u00a00\u00b701), while (v) leptin, PP<\/jats:styled-content> and PYY<\/jats:styled-content> were not significantly different. GIP<\/jats:styled-content>, GLP<\/jats:styled-content>\u20101 and amylin levels correlated positively with insulin concentrations (P<\/jats:italic>\u00a0<\u00a00\u00b7001, P<\/jats:italic>\u00a0=\u00a00\u00b7004 and P<\/jats:italic>\u00a0<\u00a00\u00b701, respectively) in all patients. Amylin and GIP<\/jats:styled-content> levels were strongly associated with triglycerides concentrations (P<\/jats:italic>\u00a0<\u00a00\u00b7001, for both peptides) in children with CD<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our study revealed a different secretion pattern of gut\u2010brain axis hormones in children with CD<\/jats:styled-content> compared with HC<\/jats:styled-content>. The alterations in the axis were more pronounced in children with both CD<\/jats:styled-content> and T1DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12193","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T06:40:07Z","timestamp":1382596807000},"page":"74-82","source":"Crossref","is-referenced-by-count":14,"title":["Incretins, amylin and other gut\u2010brain axis hormones in children with coeliac disease"],"prefix":"10.1111","volume":"44","author":[{"given":"Maria","family":"Papastamataki","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry \u2018Aghia Sophia\u2019 Children's Hospital Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Papassotiriou","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry \u2018Aghia Sophia\u2019 Children's Hospital Athens 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