{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:48:31Z","timestamp":1787014111724,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,9]],"date-time":"2013-12-09T00:00:00Z","timestamp":1386547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Chronic fatigue syndrome (\n CFS<\/jats:styled-content>\n ) patients frequently complain of muscle fatigue and abnormally slow recovery, especially of the upper limb muscles during and after activities of daily living. Furthermore, disease heterogeneity has not yet been studied in relation to recovery of muscle function in\n CFS<\/jats:styled-content>\n . Here, we examine recovery of upper limb muscle function from a fatiguing exercise in\n CFS<\/jats:styled-content>\n patients with (\n CFS<\/jats:styled-content>\n +\n FM<\/jats:styled-content>\n ) and without (\n CFS<\/jats:styled-content>\n \u2010only) comorbid fibromyalgia and compare their results with a matched inactive control group.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n In this case\u2013control study, 18\n CFS<\/jats:styled-content>\n \u2010only patients, 30\n CFS<\/jats:styled-content>\n +\n FM<\/jats:styled-content>\n patients and 30 healthy inactive controls performed a fatiguing upper limb exercise test with subsequent recovery measures.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There was no significant difference among the three groups for maximal handgrip strength of the non\u2010dominant hand. A significant worse recovery of upper limb muscle function was found in the\n CFS<\/jats:styled-content>\n +\n FM<\/jats:styled-content>\n , but not in de\n CFS<\/jats:styled-content>\n \u2010only group compared with the controls (\n P<\/jats:italic>\n \u00a0<\u00a00\u00b705).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study reveals, for the first time, delayed recovery of upper limb muscle function in\n CFS<\/jats:styled-content>\n +\n FM<\/jats:styled-content>\n , but not in\n CFS<\/jats:styled-content>\n \u2010only patients. The results underline that\n CFS<\/jats:styled-content>\n is a heterogeneous disorder suggesting that reducing the heterogeneity of the disorder in future research is important to make progress towards a better understanding and uncovering of mechanisms regarding the nature of divers impairments in these patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/eci.12201","type":"journal-article","created":{"date-parts":[[2013,11,11]],"date-time":"2013-11-11T03:00:43Z","timestamp":1384138843000},"page":"153-159","source":"Crossref","is-referenced-by-count":9,"title":["Recovery of upper limb muscle function in chronic fatigue syndrome with and without fibromyalgia"],"prefix":"10.1111","volume":"44","author":[{"given":"Kelly","family":"Ickmans","sequence":"first","affiliation":[{"name":"Pain in Motion Research Group Department of Human Physiology and Physiotherapy Faculty of Physical Education & Physiotherapy Vrije Universiteit Brussel Brussel Belgium"},{"name":"Pain in Motion Research Group Division of Musculoskeletal Physiotherapy Department of Health Care Sciences Artesis University College Antwerp Antwerp Belgium"},{"name":"Pain in Motion Research Group Department of Physical Medicine and Physiotherapy University Hospital Brussels Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mira","family":"Meeus","sequence":"additional","affiliation":[{"name":"Pain in Motion Research Group Division of Musculoskeletal Physiotherapy Department of Health Care Sciences Artesis University College Antwerp Antwerp Belgium"},{"name":"Rehabilitation Sciences and Physiotherapy Faculty of Medicine & Health Sciences Ghent University Gent Belgium"},{"name":"Pain in Motion Research Group Department of Rehabilitation Sciences and Physiotherapy Faculty of Medicine & Health Sciences University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"De Kooning","sequence":"additional","affiliation":[{"name":"Pain in Motion Research Group Department of Human Physiology and Physiotherapy Faculty of Physical Education & Physiotherapy Vrije Universiteit Brussel Brussel Belgium"},{"name":"Pain in Motion Research Group Department of Physical Medicine and Physiotherapy University Hospital Brussels Brussels Belgium"},{"name":"Department of Neurology Faculty of Medicine University of Antwerp (UA) Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Lambrecht","sequence":"additional","affiliation":[{"name":"Private practice for internal medicine Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Nijs","sequence":"additional","affiliation":[{"name":"Pain in Motion Research Group Department of Human Physiology and Physiotherapy Faculty of Physical Education & Physiotherapy Vrije Universiteit Brussel Brussel Belgium"},{"name":"Pain in Motion Research Group 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