{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:45:18Z","timestamp":1769154318281,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,27]],"date-time":"2013-12-27T00:00:00Z","timestamp":1388102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies demonstrated the prognostic importance of concomitant polyvascular disease in patients with coronary artery disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>). However, the significance of the number of diseased vascular territories and subclinical disease is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The number of diseased vascular territories was evaluated in 2299 percutaneous coronary intervention (<jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>) patients. Vascular disease was defined by documented atherosclerotic disease, either diagnosed in the medical history (clinical) or at the standardized cardiovascular screening (subclinical). The following territories were evaluated: cerebrovascular disease, peripheral arterial disease, abdominal aortic aneurysm and vascular renal disease. The outcome measures were all\u2010cause mortality, cardiovascular mortality and a composite cardiovascular endpoint (myocardial infarction, stroke, cardiovascular mortality). Patients with monovascular disease (<jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>) served as the reference category. Hazard ratios (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s) were adjusted for baseline characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean follow\u2010up was 7\u00b73\u00a0years. The <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s (95% confidence interval) for patients with two diseased territories compared to monovascular disease were for all\u2010cause mortality 1\u00b760 (1\u00b714\u20132\u00b725), cardiovascular mortality 2\u00b713 (1\u00b729\u20133\u00b750) and the combined cardiovascular endpoint 1\u00b766 (1\u00b720\u20132\u00b731). Moreover, the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s (95% confidence intervals) for patients with more than two diseased territories compared to monovascular disease were for all\u2010cause mortality 3\u00b781 (2\u00b745\u20135\u00b792), cardiovascular mortality 4\u00b740 (2\u00b732\u20138\u00b735) and the combined cardiovascular endpoint 2\u00b775 (1\u00b769\u20134\u00b747). The <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s of patients with subclinical disease were comparable to the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>s of patients with clinical disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients undergoing <jats:styled-content style=\"fixed-case\">PCI<\/jats:styled-content>, the presence of subclinical and clinical polyvascular disease is associated with an increased long\u2010term mortality and morbidity. Moreover, the outcome is highly influenced by the number of diseased territories.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12222","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T17:34:46Z","timestamp":1385573686000},"page":"231-239","source":"Crossref","is-referenced-by-count":18,"title":["The impact of polyvascular disease on long\u2010term outcome in percutaneous coronary intervention patients"],"prefix":"10.1111","volume":"44","author":[{"given":"Manon G.","family":"van der Meer","sequence":"first","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten J.","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"van der 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