{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T01:49:07Z","timestamp":1772070547734,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T00:00:00Z","timestamp":1388620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vascular endothelial dysfunction and intima\u2010media thickness are characteristic aspects of several vasculitides. We investigated retrospectively the impact of steroid treatment on endothelial dysfunction and intima\u2010media thickness in giant\u2010cell arteritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010one patients with giant\u2010cell arteritis (28 female and 13 male) underwent flow\u2010mediated dilatation, a marker of endothelial function, and carotid intima\u2010media thickness within 24\u00a0h after diagnosis and 6\u00a0months thereafter. Both parameters were investigated in 41 patients of an age\u2010 and gender\u2010matched control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Brachial flow\u2010mediated dilatation response at baseline was 3\u00b74% (0\u00b72, 8\u00b70) and 1\u00b77% (0\u00b72, 4\u00b78) in giant\u2010cell arteritis patients and control group, respectively. After 6\u00a0months treatment, flow\u2010mediated dilatation response was 2\u00b78% (0\u00b74, 4\u00b78) in patients with giant\u2010cell arteritis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7066) and 1\u00b74% (0\u00b71, 5\u00b75) in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7741). In contrast, mean carotid intima\u2010media thickness of giant\u2010cell arteritis patients improved significantly between baseline [1\u00b70\u00a0mm (0\u00b779, 1\u00b72)] and 6\u2010month follow\u2010up [0\u00b782\u00a0mm (0\u00b77, 1\u00b704), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001]. Subjects with additional symptoms of polymyalgia rheumatica had a notable enlargement of carotid intima\u2010media thickness [1\u00b723\u00a0mm (1\u00b714, 2\u00b709)] compared to giant\u2010cell arteritis patients without polymyalgia rheumatica at baseline [0\u00b791\u00a0mm (0\u00b776, 1\u00b704), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001] and 6\u2010month follow\u2010up [1\u00b716\u00a0mm (0\u00b780, 1\u00b726) vs. 0\u00b777\u00a0mm (0\u00b768, 0\u00b788), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Steroid therapy has no influence on endothelial function but does significantly improve carotid intima\u2010media thickness in giant\u2010cell arteritis. This divergence of endothelial function and intima\u2010media thickness reflects the specifity of giant\u2010cell arteritis for cerebrovascular arteries thereby sparing the brachial arteries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12227","type":"journal-article","created":{"date-parts":[[2013,12,12]],"date-time":"2013-12-12T17:46:34Z","timestamp":1386870394000},"page":"249-256","source":"Crossref","is-referenced-by-count":19,"title":["Endothelial function and carotid intima\u2010media thickness in giant\u2010cell arteritis"],"prefix":"10.1111","volume":"44","author":[{"given":"Franz","family":"Hafner","sequence":"first","affiliation":[{"name":"Division of Angiology Department of Internal Medicine Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Haas","sequence":"additional","affiliation":[{"name":"Division of Angiology Department of Internal Medicine Medical University of Graz Graz 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