{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:44:21Z","timestamp":1790361861484,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T00:00:00Z","timestamp":1390176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Investigation"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The serine protease thrombin is the most potent platelet agonist and acts mainly via protease\u2010activated receptors (<jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>)\u20101 and \u20104. Data linking <jats:italic>in vitro<\/jats:italic> thrombin generation potential with <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\u20101\u2010mediated platelet activation and adverse events after angioplasty and stenting are missing, so far.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>In this prospective cohort study, thrombin generation potential was measured with a commercially available assay in 108 patients undergoing infrainguinal angioplasty and stenting for lower extremity artery disease classified as Rutherford stages of peripheral arterial disease (<jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>) 2\u20103. Thrombin receptor\u2010activating peptide (<jats:styled-content style=\"fixed-case\">TRAP<\/jats:styled-content>)\u20106\u2010inducible P\u2010selectin expression was determined by flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and four patients entered statistical analysis. Peak thrombin generation potential correlated inversely with TRAP\u20106\u2010inducible P\u2010selectin (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b72, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Target vessel restenosis or reocclusion (TVR) occurred in 37 patients (35\u00b76%), and the composite atherothrombotic endpoint of myocardial infarction, ischaemic stroke or transient ischaemic attack, and cardiovascular death occurred in seven patients (6\u00b77%) within 2\u2010year follow\u2010up. Peak thrombin generation was similar between patients without and with TVR [465\u00a0nM (354\u2013566\u00a0nM) vs. 440 nM (355\u2013523\u00a0nM), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b76], but significantly lower in patients with the atherothrombotic endpoint than in patients without atherothrombotic events [357\u00a0nM (219\u2013389\u00a0nM) vs. 463\u00a0nM (362\u201355\u00a0nM), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703]. Further, low thrombin generation potential was associated with an 11\u00b77\u2010fold (95% CI 1\u00b74\u201397\u00b76; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702) increased risk of future atherothrombotic events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Residual thrombin generation potential is inversely correlated with <jats:styled-content style=\"fixed-case\">PAR<\/jats:styled-content>\u20101\u2010mediated platelet activation and linked to the occurrence of atherothrombotic events in patients with <jats:styled-content style=\"fixed-case\">PAD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/eci.12236","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T08:40:55Z","timestamp":1388652055000},"page":"319-324","source":"Crossref","is-referenced-by-count":20,"title":["Residual thrombin generation potential is inversely linked to the occurrence of atherothrombotic events in patients with peripheral arterial disease"],"prefix":"10.1111","volume":"44","author":[{"given":"Thomas","family":"Gremmel","sequence":"first","affiliation":[{"name":"Division of Angiology Department of Internal Medicine II Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Koppensteiner","sequence":"additional","affiliation":[{"name":"Division of Angiology Department of Internal Medicine II Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Ay","sequence":"additional","affiliation":[{"name":"Clinical Division of Haematology and Haemostaseology Department of Internal Medicine I Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Panzer","sequence":"additional","affiliation":[{"name":"Department of Blood Group Serology and Transfusion Medicine Medical University of Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6042"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.574830"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12094"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.09.103"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05612.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-07-0408"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.182188"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02234.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537100410001711505"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2013.04.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03766.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12021"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03184.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-03-0185"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.8294"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.4.397"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH13\u201007\u20100558."}],"container-title":["European Journal of Clinical Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Feci.12236","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/eci.12236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T17:19:30Z","timestamp":1696353570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12236"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,20]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1111\/eci.12236"],"URL":"https:\/\/doi.org\/10.1111\/eci.12236","archive":["Portico"],"relation":{},"ISSN":["0014-2972","1365-2362"],"issn-type":[{"value":"0014-2972","type":"print"},{"value":"1365-2362","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,20]]}}}